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Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid

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Main Authors: Siti Hajar, Alias, Nor Aziah, Buang, Alias, Mohd Yusof, Mohd Lokman, Ibrahim
Other Authors: sitihajar404@perlis.uitm.edu.my
Format: Article
Language:English
Published: Universiti Malaysia Perlis 2016
Subjects:
Multiwalled carbon nanotubes
Functionalized
Druq loading
Druq released
Aspirin
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41308
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spelling my.unimap-413082017-11-21T02:04:32Z Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid Siti Hajar, Alias Nor Aziah, Buang Alias, Mohd Yusof Mohd Lokman, Ibrahim sitihajar404@perlis.uitm.edu.my Multiwalled carbon nanotubes Functionalized Druq loading Druq released Aspirin Link to publisher's homepage at http://ijneam.unimap.edu.my/ Carbon nanotubes (CNTs) have been proposed and actively explored as innovative carriers for drug delivery applications. The functionalization of carbon nanotubes can improve substantially their dispersability and biocompatibility profile, thus offering the potential exploitation of carbon nanotubes in drug administration. In this study, the multiwalled carbon nanotubes (MWCNTs) were functionalized using concentrated nitric acid (68%) and supfuric acid (98%) in the ration 3:1 volume per volume by sonication techniques and were characterized using various characterization instruments. The generation of carboxylic groups was proven by FT-IR spectroscopy. In addition, the loading of aspirin (ASA) drug onto functionalized MWCNTs was done by sonication technique at different concentration of ASA drug solutions and at different sonication time. The presence of ASA attached onto functionalized MWCNTs was determined by FT-IR spectroscopy. The results from UV-Vis Spectrophtometer gave the percentage of ASA loading onto functionalized MWCNTs with the amount of 77.64% (77.64 mg) at 30 000 ppm for 5 hours sonication. From the release study of ASA in Simulated Body Fluid (SBF) at 37ºC (human body temperature) and 39ºC (fever temperature), the results show a fast release of ASA from ASA-f-MWCNTs composite for the first 5 hours compared to the commercialized aspirin tablets and followed by a controlled release at the following hours. It reveals that MWCNTs have the ability to improve the pharmacokinetics of ASA in the biomedical applications, thus it can be used to improve the drug delivery system. 2016-04-22T07:45:39Z 2016-04-22T07:45:39Z 2014 Article International Journal of Nanoelectronics and Materials, vol.7 (1), 2014, pages 35-43 1985-5761 (Printed) 1997-4434 (Online) http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41308 en Universiti Malaysia Perlis
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Multiwalled carbon nanotubes
Functionalized
Druq loading
Druq released
Aspirin
spellingShingle Multiwalled carbon nanotubes
Functionalized
Druq loading
Druq released
Aspirin
Siti Hajar, Alias
Nor Aziah, Buang
Alias, Mohd Yusof
Mohd Lokman, Ibrahim
Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
description Link to publisher's homepage at http://ijneam.unimap.edu.my/
author2 sitihajar404@perlis.uitm.edu.my
author_facet sitihajar404@perlis.uitm.edu.my
Siti Hajar, Alias
Nor Aziah, Buang
Alias, Mohd Yusof
Mohd Lokman, Ibrahim
format Article
author Siti Hajar, Alias
Nor Aziah, Buang
Alias, Mohd Yusof
Mohd Lokman, Ibrahim
author_sort Siti Hajar, Alias
title Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
title_short Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
title_full Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
title_fullStr Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
title_full_unstemmed Aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
title_sort aspirin adsorption on multiwalled carbon nanotubes and its release characteristics in simulated body fluid
publisher Universiti Malaysia Perlis
publishDate 2016
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41308
_version_ 1643802794106290176
score 13.214268

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