Application of gold nanoparticles for electrochemical DNA biosensor
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2015
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my.unimap-394402015-04-13T08:07:54Z Application of gold nanoparticles for electrochemical DNA biosensor Ahmed Mishaal, Mohammed Ruslinda, Abdul Rahim, Dr. Ibraheem Jaleel, Ibraheem Foo, Kai Loong Hasrul Hisham, Che Ahmad Uda, Hashim, Prof. Dr. Yarub, Al-Douri, Assoc. Prof. Dr. Mishal78_2010@yahoo.com ruslinda@unimap.edu.my elitefoo@yahoo.com hasrulhisham@unimap.edu.my uda@unimap.edu.my yarub@unimap.edu.my Biosensors Capacitance Metal nanoparticles Capacitance values DNA hybridization Gold nanoparticles (GNPs) Link to publisher's homepage at http://www.hindawi.com/ An electrochemical DNA biosensor was successfully fabricated by using (3-aminopropyl)triethoxysilane (APTES) as a linker molecule combined with the gold nanoparticles (GNPs) on thermally oxidized SiOthin films. The SiOthin films surface was chemically modified with a mixture of APTES and GNPs for DNA detection in different time periods of 30 min, 1 hour, 2 hours, and 4 hours, respectively. The DNA immobilization and hybridization were conducted by measuring the differences of the capacitance value within the frequency range of 1 Hz to 1 MHz. The capacitance values for DNA immobilization were 160 F, 77.8 F, 70 F, and 64.6 F, respectively, with the period of time from 30 min to 4 hours. Meanwhile the capacitance values for DNA hybridization were 44 F, 54 F, 55 F, and 61.5 F, respectively. The capacitance value of bare SiOthin film was 0.42 F, which was set as a base line for a reference in DNA detection. The differences of the capacitance value between the DNA immobilization and hybridization revealed that the modified SiOthin films using APTES and GNPs were successfully developed for DNA detection. 2015-04-13T08:07:53Z 2015-04-13T08:07:53Z 2014 Article Journal of Nanomaterials, vol. 2014, 2014, pages 1-7 1687-4110 http://www.hindawi.com/journals/jnm/2014/683460/ http://dspace.unimap.edu.my:80/xmlui/handle/123456789/39440 en Hindawi Publishing Corporation |
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Universiti Malaysia Perlis |
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| language |
English |
| topic |
Biosensors Capacitance Metal nanoparticles Capacitance values DNA hybridization Gold nanoparticles (GNPs) |
| spellingShingle |
Biosensors Capacitance Metal nanoparticles Capacitance values DNA hybridization Gold nanoparticles (GNPs) Ahmed Mishaal, Mohammed Ruslinda, Abdul Rahim, Dr. Ibraheem Jaleel, Ibraheem Foo, Kai Loong Hasrul Hisham, Che Ahmad Uda, Hashim, Prof. Dr. Yarub, Al-Douri, Assoc. Prof. Dr. Application of gold nanoparticles for electrochemical DNA biosensor |
| description |
Link to publisher's homepage at http://www.hindawi.com/ |
| author2 |
Mishal78_2010@yahoo.com |
| author_facet |
Mishal78_2010@yahoo.com Ahmed Mishaal, Mohammed Ruslinda, Abdul Rahim, Dr. Ibraheem Jaleel, Ibraheem Foo, Kai Loong Hasrul Hisham, Che Ahmad Uda, Hashim, Prof. Dr. Yarub, Al-Douri, Assoc. Prof. Dr. |
| format |
Article |
| author |
Ahmed Mishaal, Mohammed Ruslinda, Abdul Rahim, Dr. Ibraheem Jaleel, Ibraheem Foo, Kai Loong Hasrul Hisham, Che Ahmad Uda, Hashim, Prof. Dr. Yarub, Al-Douri, Assoc. Prof. Dr. |
| author_sort |
Ahmed Mishaal, Mohammed |
| title |
Application of gold nanoparticles for electrochemical DNA biosensor |
| title_short |
Application of gold nanoparticles for electrochemical DNA biosensor |
| title_full |
Application of gold nanoparticles for electrochemical DNA biosensor |
| title_fullStr |
Application of gold nanoparticles for electrochemical DNA biosensor |
| title_full_unstemmed |
Application of gold nanoparticles for electrochemical DNA biosensor |
| title_sort |
application of gold nanoparticles for electrochemical dna biosensor |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2015 |
| url |
http://dspace.unimap.edu.my:80/xmlui/handle/123456789/39440 |
| _version_ |
1643799067277393920 |
| score |
13.214268 |