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Functionalized three-dimensional carbon microarrays for cancer biomarker detection

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Bibliographic Details
Main Authors: Penmatsa, Varun, Ruslinda, Abdul Rahim, Dr., Beidaghi, Majid, Kawarada, Hiroshi, Chunlei, Wang
Other Authors: ruslinda@unimap.edu.my
Format: Article
Language:English
Published: Electrochemical Society 2014
Subjects:
Cancer biomarker detections
Carbon
Diseases
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/34916
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spelling my.unimap-349162014-06-01T04:45:18Z Functionalized three-dimensional carbon microarrays for cancer biomarker detection Penmatsa, Varun Ruslinda, Abdul Rahim, Dr. Beidaghi, Majid Kawarada, Hiroshi Chunlei, Wang ruslinda@unimap.edu.my Cancer biomarker detections Carbon Diseases Link to publisher's homepage at http://www.electrochem.org/ A label-free detection strategy for the detection of platelet-derived growth factor (PDGF-BB) oncoprotein detection using signaling aptamer/protein binding complex is reported. The 3D carbon microarrays detection platform was fabricated by pyrolyzing patterned photoresist and surface functionalized using directamination technique. The detection strategy is based on the release of TOTO intercalating dye from the target binding aptamer's stem structure when it captures PDGF. The sensor showed near linear relationship between the relative fluorescence difference and protein concentration with a very good detection limit of 5 pmol. This detection strategy is promising for the potential detection of different cancer biomarkers and proteins. 2014-06-01T04:45:18Z 2014-06-01T04:45:18Z 2013 Article ECS Transactions, vol. 45(15), 2013, pages 7-14 978-162332021-8 1938-5862 http://ecst.ecsdl.org/content/45/15 http://dspace.unimap.edu.my:80/dspace/handle/123456789/34916 en Electrochemical Society
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Cancer biomarker detections
Carbon
Diseases
spellingShingle Cancer biomarker detections
Carbon
Diseases
Penmatsa, Varun
Ruslinda, Abdul Rahim, Dr.
Beidaghi, Majid
Kawarada, Hiroshi
Chunlei, Wang
Functionalized three-dimensional carbon microarrays for cancer biomarker detection
description Link to publisher's homepage at http://www.electrochem.org/
author2 ruslinda@unimap.edu.my
author_facet ruslinda@unimap.edu.my
Penmatsa, Varun
Ruslinda, Abdul Rahim, Dr.
Beidaghi, Majid
Kawarada, Hiroshi
Chunlei, Wang
format Article
author Penmatsa, Varun
Ruslinda, Abdul Rahim, Dr.
Beidaghi, Majid
Kawarada, Hiroshi
Chunlei, Wang
author_sort Penmatsa, Varun
title Functionalized three-dimensional carbon microarrays for cancer biomarker detection
title_short Functionalized three-dimensional carbon microarrays for cancer biomarker detection
title_full Functionalized three-dimensional carbon microarrays for cancer biomarker detection
title_fullStr Functionalized three-dimensional carbon microarrays for cancer biomarker detection
title_full_unstemmed Functionalized three-dimensional carbon microarrays for cancer biomarker detection
title_sort functionalized three-dimensional carbon microarrays for cancer biomarker detection
publisher Electrochemical Society
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/34916
_version_ 1643797654653632512
score 13.222552

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