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Prolonging glucose sensor's performance in In Vivo environment

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Main Authors: Nashrul Fazli, Mohd Nasir, Dr., Yang Ying
Other Authors: nashrul@unimap.edu.my
Format: Article
Language:English
Published: Faculty of Computer Science & Information Technology, University of Malaya 2014
Subjects:
Biosensor
Glucose sensor
Immobilization technique
Sol gel technique
Biocompatibility
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/34818
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spelling my.unimap-348182014-05-28T04:37:42Z Prolonging glucose sensor's performance in In Vivo environment Nashrul Fazli, Mohd Nasir, Dr. Yang Ying nashrul@unimap.edu.my Biosensor Glucose sensor Immobilization technique Sol gel technique Biocompatibility Link to publisher's homepage at http://ejum.fsktm.um.edu.my/ In this paper, a sol gel based needle type biosensor using 3-glycidoxypropyl dimethylethoxy silane, as silane agent was developed to improve the immobilization efficiency of glucose oxidase (GOD). The glucose sensor was coated with 3C-copolymer as the outmost layer to increase sensor’s biocompatibility. The biosensor’s performance fabricated by this technique was compared with the conventional sensors which use glutaraldehyde as the cross link agent for immobilization of GOD. Both types of sensor were immersed in 20 mM glucose solution for more than 24 hours and the sol gel based sensor exhibited better stability. This indicates that the sol gel immobilization technique applied is able to retain enzyme for longer time of period compared to the conventional method. Furthermore, the study revealed once the sensors were tested in a glucose solution containing 1% bovine serum albumin in a long term stability test, the performance of the sol gel based sensor coated with 3C-copolymer was not affected considerably by protein adsorption, which was a vital character for an in vivo biosensor. 2014-05-28T04:37:42Z 2014-05-28T04:37:42Z 2006 Article Engineering e-Transaction, vol. 1(2), 2006, pages 1-4 1823-6379 http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=399 http://dspace.unimap.edu.my:80/dspace/handle/123456789/34818 en Faculty of Computer Science & Information Technology, University of Malaya
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Biosensor
Glucose sensor
Immobilization technique
Sol gel technique
Biocompatibility
spellingShingle Biosensor
Glucose sensor
Immobilization technique
Sol gel technique
Biocompatibility
Nashrul Fazli, Mohd Nasir, Dr.
Yang Ying
Prolonging glucose sensor's performance in In Vivo environment
description Link to publisher's homepage at http://ejum.fsktm.um.edu.my/
author2 nashrul@unimap.edu.my
author_facet nashrul@unimap.edu.my
Nashrul Fazli, Mohd Nasir, Dr.
Yang Ying
format Article
author Nashrul Fazli, Mohd Nasir, Dr.
Yang Ying
author_sort Nashrul Fazli, Mohd Nasir, Dr.
title Prolonging glucose sensor's performance in In Vivo environment
title_short Prolonging glucose sensor's performance in In Vivo environment
title_full Prolonging glucose sensor's performance in In Vivo environment
title_fullStr Prolonging glucose sensor's performance in In Vivo environment
title_full_unstemmed Prolonging glucose sensor's performance in In Vivo environment
title_sort prolonging glucose sensor's performance in in vivo environment
publisher Faculty of Computer Science & Information Technology, University of Malaya
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/34818
_version_ 1643797607976271872
score 13.214268

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