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Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration

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Main Authors: Martínez, Martina Brito, Nora, Jullok, Negrín, Zenaida Rodríguez, Bruggen, Bart Van der, Luis, Patricia
Other Authors: nora.jullok@cit.kuleuven.be
Format: Article
Language:English
Published: Elsevier B.V. 2014
Subjects:
Active pharmaceutical compounds
Dead-end nanofiltration
Organic solvent nanofiltration
Recycling
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/34257
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spelling my.unimap-342572014-05-05T08:32:02Z Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration Martínez, Martina Brito Nora, Jullok Negrín, Zenaida Rodríguez Bruggen, Bart Van der Luis, Patricia nora.jullok@cit.kuleuven.be Active pharmaceutical compounds Dead-end nanofiltration Organic solvent nanofiltration Recycling Link to publisher's homepage at https://www.elsevier.com/‎ The recovery of the active pharmaceutical ingredient 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane (denoted as G-1) from residual ethanol produced during the purification of G-1 was studied by using solvent resistant nanofiltration. The effect of the impurities pyridine, acetic anhydride and bromine on the process performance was studied.Four commercial nanofiltration membranes were studied in a stirred dead-end filtration module, i.e. NF 90, NF 270, Duramem 150 and BW30XLE, supplied by Evonik Industries and Filmtec (Dow). The membranes Duramem 150 and NF 90 showed the best performance, allowing a recovery of G-1 of above 60% in one stage. The separation factor of pyridine/G-1 for Duramem 150 and NF 90 was found to be higher than 2 for synthetic mixtures containing 26.75. g/L of G-1, 5.35. g/L of pyridine, 0.149. g/L of bromine and 0.105. g/L of acetic anhydride in ethanol. It was found that when using dead-end filtration, the recovery of G-1 is low when a high purity is required; both parameters cannot be optimized together. However, it is shown that with a sequence of filtrations, the recovery can be significantly improved at a given purity of G-1. These results indicate that the application of organic solvent nanofiltration for the recycling of valuable pharmaceutical compounds is feasible in realistic conditions 2014-05-05T08:32:02Z 2014-05-05T08:32:02Z 2013-08 Article Chemical Engineering and Processing: Process Intensification, vol. 70, 2013, pages 241-249 0255-2701 http://www.sciencedirect.com/science/article/pii/S0255270113000834 http://dspace.unimap.edu.my:80/dspace/handle/123456789/34257 en Elsevier B.V.
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Active pharmaceutical compounds
Dead-end nanofiltration
Organic solvent nanofiltration
Recycling
spellingShingle Active pharmaceutical compounds
Dead-end nanofiltration
Organic solvent nanofiltration
Recycling
Martínez, Martina Brito
Nora, Jullok
Negrín, Zenaida Rodríguez
Bruggen, Bart Van der
Luis, Patricia
Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
description Link to publisher's homepage at https://www.elsevier.com/‎
author2 nora.jullok@cit.kuleuven.be
author_facet nora.jullok@cit.kuleuven.be
Martínez, Martina Brito
Nora, Jullok
Negrín, Zenaida Rodríguez
Bruggen, Bart Van der
Luis, Patricia
format Article
author Martínez, Martina Brito
Nora, Jullok
Negrín, Zenaida Rodríguez
Bruggen, Bart Van der
Luis, Patricia
author_sort Martínez, Martina Brito
title Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
title_short Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
title_full Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
title_fullStr Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
title_full_unstemmed Effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
title_sort effect of impurities in the recovery of 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane using nanofiltration
publisher Elsevier B.V.
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/34257
_version_ 1643797428606861312
score 13.154949

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