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The relationship between age and the manifestations of and mortality associated with severe malaria.

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Main Authors: Dondorp, Arjen M., Lee, Sue J, Faiz, Md Abul, Mishra, Saroj K, Price, Ric N, Tjitra, Emiliana, Than, Marlar, Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr., Mohanty, Sanjib, Emran, Yunus, Ridwanur, Rahman, Nosten, Francois, Anstey, Nicholas M., Day, Nicholas P. J., White, Nicholas J.
Other Authors: sue@tropmedres.ac
Format: Article
Language:English
Published: Oxford University Press 2014
Subjects:
Severe malaria
Adult
Age distribution
Anemia
Asia
Mortality
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/33578
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spelling my.unimap-335782014-04-10T02:35:06Z The relationship between age and the manifestations of and mortality associated with severe malaria. Dondorp, Arjen M. Lee, Sue J Faiz, Md Abul Mishra, Saroj K Price, Ric N Tjitra, Emiliana Than, Marlar Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr. Mohanty, Sanjib Emran, Yunus Ridwanur, Rahman Nosten, Francois Anstey, Nicholas M. Day, Nicholas P. J. White, Nicholas J. sue@tropmedres.ac iqbalomar@unimap.edu.my Severe malaria Adult Age distribution Anemia Asia Mortality Link to publisher's homepage at http://cid.oxfordjournals.org/ Background. The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain. Methods. In a large, multicenter treatment trial conducted in Asia, the presenting manifestations and outcome of severe malaria were analyzed in relation to age. Results. Among 1050 patients with severe malaria, the mortality increased stepwise, from 6.1% in children (age, <10 years) to 36.5% in patients aged >50 years (P < .001). Compared with adults aged 21-50 years, the decreased risk of death among children (adjusted odds ratio, 0.06; 95% confidence interval, 0.01-0.23; P < .001) and the increased risk of death among patients aged >50 years (adjusted odds ratio, 1.88; 95% confidence interval, 1.01-3.52; P = .046) was independent of the variation in presenting manifestations. The incidence of anemia and convulsions decreased with age, whereas the incidence of hyperparasitemia, jaundice, and renal insufficiency increased with age. Coma and metabolic acidosis did not vary with age and were the strongest predictors of a fatal outcome. The number of severity signs at hospital admission also had a strong prognostic value. Conclusion. Presenting syndromes in severe malaria depend on age, although the incidence and the strong prognostic significance of coma and acidosis are similar at all ages. Age is an independent risk factor for a fatal outcome of the disease. 2014-04-10T02:35:06Z 2014-04-10T02:35:06Z 2008 Article Clinical Infectious Diseases, vol. 47(2), 2008, pages 151-157 1058-4838 (Print) 1537-6591 (Online) http://dspace.unimap.edu.my:80/dspace/handle/123456789/33578 http://cid.oxfordjournals.org/content/47/2/151.long 10.1086/589287 en Oxford University Press
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Severe malaria
Adult
Age distribution
Anemia
Asia
Mortality
spellingShingle Severe malaria
Adult
Age distribution
Anemia
Asia
Mortality
Dondorp, Arjen M.
Lee, Sue J
Faiz, Md Abul
Mishra, Saroj K
Price, Ric N
Tjitra, Emiliana
Than, Marlar
Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr.
Mohanty, Sanjib
Emran, Yunus
Ridwanur, Rahman
Nosten, Francois
Anstey, Nicholas M.
Day, Nicholas P. J.
White, Nicholas J.
The relationship between age and the manifestations of and mortality associated with severe malaria.
description Link to publisher's homepage at http://cid.oxfordjournals.org/
author2 sue@tropmedres.ac
author_facet sue@tropmedres.ac
Dondorp, Arjen M.
Lee, Sue J
Faiz, Md Abul
Mishra, Saroj K
Price, Ric N
Tjitra, Emiliana
Than, Marlar
Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr.
Mohanty, Sanjib
Emran, Yunus
Ridwanur, Rahman
Nosten, Francois
Anstey, Nicholas M.
Day, Nicholas P. J.
White, Nicholas J.
format Article
author Dondorp, Arjen M.
Lee, Sue J
Faiz, Md Abul
Mishra, Saroj K
Price, Ric N
Tjitra, Emiliana
Than, Marlar
Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr.
Mohanty, Sanjib
Emran, Yunus
Ridwanur, Rahman
Nosten, Francois
Anstey, Nicholas M.
Day, Nicholas P. J.
White, Nicholas J.
author_sort Dondorp, Arjen M.
title The relationship between age and the manifestations of and mortality associated with severe malaria.
title_short The relationship between age and the manifestations of and mortality associated with severe malaria.
title_full The relationship between age and the manifestations of and mortality associated with severe malaria.
title_fullStr The relationship between age and the manifestations of and mortality associated with severe malaria.
title_full_unstemmed The relationship between age and the manifestations of and mortality associated with severe malaria.
title_sort relationship between age and the manifestations of and mortality associated with severe malaria.
publisher Oxford University Press
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/33578
_version_ 1643797217737179136
score 13.214268

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