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The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria

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Main Authors: Shwe, Tin, Myint, Pe Than, Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr., Myint, Win, Soe, Lin
Other Authors: iqbalomar@unimap.edu.my
Format: Article
Language:English
Published: Elsevier Ltd. 2014
Subjects:
Plasmodium falciparum malaria
Cerebral signs
Mefloquine-artemether
Drug therapy
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/33569
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spelling my.unimap-335692014-04-09T17:07:21Z The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria Shwe, Tin Myint, Pe Than Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr. Myint, Win Soe, Lin iqbalomar@unimap.edu.my Plasmodium falciparum malaria Cerebral signs Mefloquine-artemether Drug therapy Link to publisher's homepage at http://www.sciencedirect.com/ 30 pairs of patients with complicated Plasmodium falciparum malaria (with anaemia, hyperpyrexia, jaundice or more than 5% of erythrocytes parasitized) were studied. Patients with cerebral signs and symptoms were excluded. One group of patients was treated with oral mefloquine (750 mg) and artemether (600 mg by injection, 200 mg initially and 100 mg every 12 h). The second group of patients was treated with quinine (10 mg/kg orally every 8 h for 7 d). All patients were admitted to hospital for 7 d and examined subsequently on days 14, 21 and 28. All those treated with mefloquine plus artemether survived and their parasite clearance time and fever clearance time were significantly shorter than those of patients receiving quinine. 2 patients treated with quinine died. There was no recrudescence in any patient of either group. 2014-04-09T17:07:21Z 2014-04-09T17:07:21Z 1988 Article Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 82(5), 1988, pages 665-666 1878-3503 (Online) 0035-9203 (Print) http://dspace.unimap.edu.my:80/dspace/handle/123456789/33569 http://dx.doi.org/10.1016/0035-9203(88)90187-3 http://www.sciencedirect.com/science/article/pii/0035920388901873 en Elsevier Ltd.
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Plasmodium falciparum malaria
Cerebral signs
Mefloquine-artemether
Drug therapy
spellingShingle Plasmodium falciparum malaria
Cerebral signs
Mefloquine-artemether
Drug therapy
Shwe, Tin
Myint, Pe Than
Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr.
Myint, Win
Soe, Lin
The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
description Link to publisher's homepage at http://www.sciencedirect.com/
author2 iqbalomar@unimap.edu.my
author_facet iqbalomar@unimap.edu.my
Shwe, Tin
Myint, Pe Than
Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr.
Myint, Win
Soe, Lin
format Article
author Shwe, Tin
Myint, Pe Than
Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr.
Myint, Win
Soe, Lin
author_sort Shwe, Tin
title The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
title_short The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
title_full The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
title_fullStr The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
title_full_unstemmed The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
title_sort effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
publisher Elsevier Ltd.
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/33569
_version_ 1643797216247152640
score 13.214268

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