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Membrane crystallization for the recovery of a pharmaceutical compound from waste streams

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Main Authors: Brito Martínez, M., Nora, Jullok, Rodríguez Negrín, Z., Van der Bruggen, B., Luis, P.
Other Authors: patricia.luis@uclouvain.be
Format: Article
Language:English
Published: Elsevier 2014
Subjects:
Membrane crystallization
Active pharmaceutical ingredient
Vitrofural
Aqueous waste streams
Mass transfer coefficients
Economic evaluation
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/32773
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spelling my.unimap-327732014-03-15T03:06:28Z Membrane crystallization for the recovery of a pharmaceutical compound from waste streams Brito Martínez, M. Nora, Jullok Rodríguez Negrín, Z. Van der Bruggen, B. Luis, P. patricia.luis@uclouvain.be Membrane crystallization Active pharmaceutical ingredient Vitrofural Aqueous waste streams Mass transfer coefficients Economic evaluation Link to publisher's homepage at http://www.elsevier.com The recovery of the active pharmaceutical compound 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane (denoted as G-1) in a crystalline form from waste aqueous solutions using membrane crystallization is addressed in this work. The process conditions were evaluated, observing that a low flowrate of the feed solution (5.0 ml/min) is required to crystallize G-1. In addition, the use of Vitrofural as the feed solution, which is a mixture of G-1 and PEG, allows operating with higher concentrations due to the higher solubility of Vitrofural in water. However, the presence of PEG affects the mass transfer, leading to a lower transmembrane flux compared to the use of pure G-1. SEM images were used to evaluate the surface morphology of the crystallized G-1. It was concluded that the crystals obtained by membrane crystallization have the same morphology as the commercial G-1. Thus, the application of membrane crystallization for G-1 recovery can be considered as a novel technique with high potential to recover pharmaceutical compounds from waste streams. 2014-03-15T03:06:28Z 2014-03-15T03:06:28Z 2014-02 Article Chemical Engineering Research and Design, vol.92 (2), 2014, pages 264–272 0263-8762 http://dspace.unimap.edu.my:80/dspace/handle/123456789/32773 http://www.sciencedirect.com/science/article/pii/S0263876213003262 http://dx.doi.org/10.1016/j.cherd.2013.07.029 en Elsevier
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Membrane crystallization
Active pharmaceutical ingredient
Vitrofural
Aqueous waste streams
Mass transfer coefficients
Economic evaluation
spellingShingle Membrane crystallization
Active pharmaceutical ingredient
Vitrofural
Aqueous waste streams
Mass transfer coefficients
Economic evaluation
Brito Martínez, M.
Nora, Jullok
Rodríguez Negrín, Z.
Van der Bruggen, B.
Luis, P.
Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
description Link to publisher's homepage at http://www.elsevier.com
author2 patricia.luis@uclouvain.be
author_facet patricia.luis@uclouvain.be
Brito Martínez, M.
Nora, Jullok
Rodríguez Negrín, Z.
Van der Bruggen, B.
Luis, P.
format Article
author Brito Martínez, M.
Nora, Jullok
Rodríguez Negrín, Z.
Van der Bruggen, B.
Luis, P.
author_sort Brito Martínez, M.
title Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
title_short Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
title_full Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
title_fullStr Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
title_full_unstemmed Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
title_sort membrane crystallization for the recovery of a pharmaceutical compound from waste streams
publisher Elsevier
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/32773
_version_ 1643796980948795392
score 13.214268

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