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Polymeric scaffolds for bone tissue regeneration

The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Po...

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Main Author: Grehan, Laura
Format: Other
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2013
Subjects:
Polymeric scaffolds
Bone tissue
Hydrogels
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/30903
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spelling my.unimap-309032013-12-27T08:42:23Z Polymeric scaffolds for bone tissue regeneration Grehan, Laura Polymeric scaffolds Bone tissue Hydrogels The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia Most bone graft procedures are implemented to repair bone defects stemming from injury or disease. Despite the benefits of current treatment options, limitations such as immune rejection, complicated surgical procedures and limited volume of donor tissue have necessitated the pursuit of alternatives. Hydrogels are a key group of biomaterials, resembling natural living tissue more than any other class of synthetic biomaterials. While hydrogels allow diffusion of nutrients and cellular waste necessary for cell survival in tissue engineering applications, this property also hinders localised delivery of soluble factors to the encapsulated cells, as the gel networks are equally permeable to encapsulated drug. Hot melt extrusion (HME) was therefore utilised in this study to prepare a controlled release drug delivery device which can be embeded within a PEG based hydrogel for use as a biocompatible tissue engineering scaffold which aids in the regeneration of tissue. Dissolution results revealed that the release profiles of model drug are altered by the presence of fillers. The presence of fillers also allows tuning of degradation rates, providing possibilities for their use as implants, where the rate of degradation of the scaffold should occur at the rate of formation of the new tissue, such as in bone tissue engineering. The MTT cytotoxicity assay provided data on the metabolic activity of NIH/3T3 model cell line when directly exposed to the hydrogel samples. Cell viability remained above 80% for all samples when compared to untreated control cultures. Microscopic evaluation revealed that cell morphology also appeared normal for these test specimens after 24h exposure. Overall, results obtained revealed that hot melt extrusion can be used to prepare these extended release devices which can be embedded within biocompatible scaffolds, providing osteoinductive cues and encouraging new tissue formation 2013-12-27T08:42:23Z 2013-12-27T08:42:23Z 2012-06-18 Other p. 1285 978-967-5760-11-2 http://hdl.handle.net/123456789/30903 en The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012); Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Polymeric scaffolds
Bone tissue
Hydrogels
spellingShingle Polymeric scaffolds
Bone tissue
Hydrogels
Grehan, Laura
Polymeric scaffolds for bone tissue regeneration
description The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia
format Other
author Grehan, Laura
author_facet Grehan, Laura
author_sort Grehan, Laura
title Polymeric scaffolds for bone tissue regeneration
title_short Polymeric scaffolds for bone tissue regeneration
title_full Polymeric scaffolds for bone tissue regeneration
title_fullStr Polymeric scaffolds for bone tissue regeneration
title_full_unstemmed Polymeric scaffolds for bone tissue regeneration
title_sort polymeric scaffolds for bone tissue regeneration
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2013
url http://dspace.unimap.edu.my/xmlui/handle/123456789/30903
_version_ 1643796411937980416
score 13.222552

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