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Improved solubility of hydrophobic drugs using hot melt extrusion technology

The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Po...

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Bibliographic Details
Main Author: Kenny, Elaine
Format: Other
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2013
Subjects:
Hydrophobic drugs
Hot melt extrusion technology
Bioavailability
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/30834
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spelling my.unimap-308342013-12-24T13:13:44Z Improved solubility of hydrophobic drugs using hot melt extrusion technology Kenny, Elaine Hydrophobic drugs Hot melt extrusion technology Bioavailability The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia It is estimated that about 40% of all new chemical entities have poor bioavailability because of low aqueous solubility. This percentage still increases due to combinatorial chemistry and the impact of lipophilic receptors1. Solubility is essential for the therapeutic effectiveness of the drug, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-aqueous media. Solubilisation may be affected by co-solvent water interaction, micellar solubilisation, reduction in particle size, inclusion complexes, solid dispersion, and change in polymorph 2013-12-24T13:13:44Z 2013-12-24T13:13:44Z 2012-06-18 Other p. 1284 978-967-5760-11-2 http://hdl.handle.net/123456789/30834 en The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012); Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Hydrophobic drugs
Hot melt extrusion technology
Bioavailability
spellingShingle Hydrophobic drugs
Hot melt extrusion technology
Bioavailability
Kenny, Elaine
Improved solubility of hydrophobic drugs using hot melt extrusion technology
description The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia
format Other
author Kenny, Elaine
author_facet Kenny, Elaine
author_sort Kenny, Elaine
title Improved solubility of hydrophobic drugs using hot melt extrusion technology
title_short Improved solubility of hydrophobic drugs using hot melt extrusion technology
title_full Improved solubility of hydrophobic drugs using hot melt extrusion technology
title_fullStr Improved solubility of hydrophobic drugs using hot melt extrusion technology
title_full_unstemmed Improved solubility of hydrophobic drugs using hot melt extrusion technology
title_sort improved solubility of hydrophobic drugs using hot melt extrusion technology
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2013
url http://dspace.unimap.edu.my/xmlui/handle/123456789/30834
_version_ 1643796390556467200
score 13.222552

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