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Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans

The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Po...

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Main Authors: Hughes, P.I., McEvoy, K.E., Rowan, N.J., Brady, D.B.
Other Authors: phughes@research.ait.ie
Format: Working Paper
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2013
Subjects:
Streptococcus mutans
Dental caries
Oleic acid
Linoleic acid
Antimicrobial
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/30517
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spelling my.unimap-305172013-12-16T06:11:31Z Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans Hughes, P.I. McEvoy, K.E. Rowan, N.J. Brady, D.B. phughes@research.ait.ie kmcevoy@research.ait.ie Streptococcus mutans Dental caries Oleic acid Linoleic acid Antimicrobial The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia. Objective- This study evaluated the efficacy of long-chain fatty acids, Oleic (C18:1) and Linoleic (C18:2) acid on the growth of Streptococcus mutans. S. mutans is one of the primary etiological agents associated with the onset of dental caries which is considered to be an oral health epidemic in industrialized countries. Assays were carried out to assess the viability of the oral pathogen in the presence of these long chain fatty acids (FAs). Design- The FA’s were prepared in 2% ethanol (EtOH) to ensure bacterial viability was not affected by the solvent. Concentrations of 0.1mM ranging up to 50mM were prepared for analysis. S. mutans was cultured at 37°C for 18 h in Brain Heart Infusion Broth (BHI) and assays were performed in sterile 96 well plates over a period of 24 h. Growth inhibition was recorded using optical density (OD) readings, from which they were evaluated and tabulated. Results- Linoleic acid showed significantly higher antimicrobial activity in contrast to Oleic acid. Linoleic displayed up to 97% inhibition of S. mutans growth during early stationary phase, whereas the highest inhibition by oleic acid at this point was 38%. Conclusions- Linoleic acid exhibited a higher level of antibacterial activity towards the cariogenic bacterium than its monounsaturated counterpart oleic acid. It is questionable whether the presence of a second double bond enhances the antimicrobial activity of linoleic acid. Antimicrobial FA’s such as these have worthy potential for applications within the oral healthcare industry in the reduction and prevention of carious lesions. 2013-12-16T06:11:31Z 2013-12-16T06:11:31Z 2012-06-18 Working Paper p. 501-506 978-967-5760-11-2 http://hdl.handle.net/123456789/30517 en Proceedings of the The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012); Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Streptococcus mutans
Dental caries
Oleic acid
Linoleic acid
Antimicrobial
spellingShingle Streptococcus mutans
Dental caries
Oleic acid
Linoleic acid
Antimicrobial
Hughes, P.I.
McEvoy, K.E.
Rowan, N.J.
Brady, D.B.
Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
description The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia.
author2 phughes@research.ait.ie
author_facet phughes@research.ait.ie
Hughes, P.I.
McEvoy, K.E.
Rowan, N.J.
Brady, D.B.
format Working Paper
author Hughes, P.I.
McEvoy, K.E.
Rowan, N.J.
Brady, D.B.
author_sort Hughes, P.I.
title Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
title_short Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
title_full Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
title_fullStr Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
title_full_unstemmed Effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
title_sort effects of long chain fatty acids oleic and linoleic, on the growth of the cariogenic bacterium streptococcus mutans
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2013
url http://dspace.unimap.edu.my/xmlui/handle/123456789/30517
_version_ 1643795592215789568
score 13.214268

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