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Brain structural complexity and life course cognitive change

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Main Authors: Nazahah, Mustafa, Ahearn, Trevor S., Waiter, Gordon D., Murray, Alison D., Whalley, Lawrence J., Staff, Roger T.
Other Authors: r05nm9@abdn.ac.uk
Format: Article
Language:English
Published: Elsevier B.V. 2013
Subjects:
Brain MR image
Childhood intelligence
Cognitive ageing
Crystallized intelligence
Fluid intelligence
Fractal dimension
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/27448
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spelling my.unimap-274482013-08-15T03:15:35Z Brain structural complexity and life course cognitive change Nazahah, Mustafa Ahearn, Trevor S. Waiter, Gordon D. Murray, Alison D. Whalley, Lawrence J. Staff, Roger T. r05nm9@abdn.ac.uk r.staff@biomed.abdn.ac.uk Brain MR image Childhood intelligence Cognitive ageing Crystallized intelligence Fluid intelligence Fractal dimension Link to publisher's homepage at http://www.elsevier.com/ Fractal measures such as fractal dimension (FD) can quantify the structural complexity of the brain. These have been used in clinical neuroscience to investigate brain development, ageing and in studies of psychiatric and neurological disorders. Here, we examined associations between the FD of white matter and cognitive changes across the life course in the absence of detectable brain disease. The FD was calculated from segmented cerebral white matter MR images in 217 subjects aged about 68. years, in whom archived intelligence scores from age 11. years were available. Cognitive test scores of fluid and crystallised intelligence were obtained at the time of MR imaging. Significant differences were found (intracranial volume, brain volume, white matter volume and Raven's Progressive Matrices score) between men and women at age 68. years and novel associations were found between FD and measures of cognitive change over the life course from age 11 to 68. years. Those with greater FD were found to have greater than expected fluid abilities at age 68. years than predicted by their childhood intelligence and less cognitive decline from age 11 to 68. years. These results are consistent with other reports that FD measures of cortical structural complexity increase across the early life course during maturation of the cerebral cortex and add new data to support an association between FD and cognitive ageing. 2013-08-15T03:15:35Z 2013-08-15T03:15:35Z 2012-07 Article NeuroImage, vol. 61(3), 2012, pages 694-701 1053-8119 http://www.sciencedirect.com/science/article/pii/S105381191200376X# http://hdl.handle.net/123456789/27448 en Elsevier B.V.
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Brain MR image
Childhood intelligence
Cognitive ageing
Crystallized intelligence
Fluid intelligence
Fractal dimension
spellingShingle Brain MR image
Childhood intelligence
Cognitive ageing
Crystallized intelligence
Fluid intelligence
Fractal dimension
Nazahah, Mustafa
Ahearn, Trevor S.
Waiter, Gordon D.
Murray, Alison D.
Whalley, Lawrence J.
Staff, Roger T.
Brain structural complexity and life course cognitive change
description Link to publisher's homepage at http://www.elsevier.com/
author2 r05nm9@abdn.ac.uk
author_facet r05nm9@abdn.ac.uk
Nazahah, Mustafa
Ahearn, Trevor S.
Waiter, Gordon D.
Murray, Alison D.
Whalley, Lawrence J.
Staff, Roger T.
format Article
author Nazahah, Mustafa
Ahearn, Trevor S.
Waiter, Gordon D.
Murray, Alison D.
Whalley, Lawrence J.
Staff, Roger T.
author_sort Nazahah, Mustafa
title Brain structural complexity and life course cognitive change
title_short Brain structural complexity and life course cognitive change
title_full Brain structural complexity and life course cognitive change
title_fullStr Brain structural complexity and life course cognitive change
title_full_unstemmed Brain structural complexity and life course cognitive change
title_sort brain structural complexity and life course cognitive change
publisher Elsevier B.V.
publishDate 2013
url http://dspace.unimap.edu.my/xmlui/handle/123456789/27448
_version_ 1643795266345631744
score 13.222552

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