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In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice

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Main Authors: Osama M., Al-Bataineh, Lweesy, Khaldon, Fraiwan, Loay
Other Authors: omabio@hu.edu.jo
Format: Working Paper
Language:English
Published: Institute of Electrical and Electronics Engineers (IEEE) 2012
Subjects:
Transdermal
Noninvasive
Insulin
Delivery
Ultrasound
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/21433
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spelling my.unimap-214332012-10-18T08:50:16Z In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice Osama M., Al-Bataineh Lweesy, Khaldon Fraiwan, Loay omabio@hu.edu.jo Transdermal Noninvasive Insulin Delivery Ultrasound Link to publisher's homepage at http://ieeexplore.ieee.org/ A noninvasive transdermal delivery of insulin, using piston-shaped PZT ultrasound transducers, was suggested to reduce regular pain and suffering of type 1 diabetic patients. This alternative technique is intended to replace the long-term dependence on multiple subcutaneous insulin injections. Ten rabbits and ten mice were divided equally into four groups (two control groups and two exposure groups). The animals were anesthetized using a combination of Ketamine hydrochloride and Xylazine to produce temporarily diabetic animal models during the periods of the experiments. Animals in control groups did not receive ultrasound while animals in exposure groups received ultrasound mediated delivery of insulin for 5 and 10 minutes for mice and rabbits, respectively, during the continuous driving of the transducers. Sweep driving frequency signals were assigned to each exposure group with frequency range from 100 to 200kHz. The signals were amplified to drive 30.0 mm diameter piston-shaped PZT transducers attached to the shaved skin of each exposed anesthetized animal. Custom made housing was used to create a reservoir to trap insulin between the face of the transducer and the exposed shaved abdomen areas of the animals during the delivery period. Blood glucose levels were measured depending on blood samples from the veins of the tails of the mice and the veins of the ears of the rabbits. These measurements were achieved using blood glucose meter every ten minutes for an hour starting from the delivery period. Over the recording period of 60 minutes, reduction of blood glucose levels compared to control groups were 67% and 50% for rabbits and mice, respectively. Ultrasound piston PZT transducers in the mid range frequency (100 to 200 kHz) were found feasible in transdermal insulin delivery in vivo using temporarily hyperglycemic rabbits and mice models. 2012-10-18T08:50:16Z 2012-10-18T08:50:16Z 2012-02-27 Working Paper p. 504-507 978-145771989-9 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6179069 http://hdl.handle.net/123456789/21433 en Proceedings of the International Conference on Biomedical Engineering (ICoBE 2012) Institute of Electrical and Electronics Engineers (IEEE)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Transdermal
Noninvasive
Insulin
Delivery
Ultrasound
spellingShingle Transdermal
Noninvasive
Insulin
Delivery
Ultrasound
Osama M., Al-Bataineh
Lweesy, Khaldon
Fraiwan, Loay
In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
description Link to publisher's homepage at http://ieeexplore.ieee.org/
author2 omabio@hu.edu.jo
author_facet omabio@hu.edu.jo
Osama M., Al-Bataineh
Lweesy, Khaldon
Fraiwan, Loay
format Working Paper
author Osama M., Al-Bataineh
Lweesy, Khaldon
Fraiwan, Loay
author_sort Osama M., Al-Bataineh
title In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
title_short In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
title_full In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
title_fullStr In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
title_full_unstemmed In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
title_sort in-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
publisher Institute of Electrical and Electronics Engineers (IEEE)
publishDate 2012
url http://dspace.unimap.edu.my/xmlui/handle/123456789/21433
_version_ 1643793397382643712
score 13.214268

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