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Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)

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Bibliographic Details
Main Author: Ooi, Ai Chiaw
Other Authors: Hairul Nazirah Abdul Halim
Format: Learning Object
Language:English
Published: Universiti Malaysia Perlis 2011
Subjects:
(R) - amlodipine
Design of Experiment (DOE)
Biphasic recognition chiral extraction (BRCE)
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/16156
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spelling my.unimap-161562017-11-29T08:05:48Z Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE) Ooi, Ai Chiaw Hairul Nazirah Abdul Halim (R) - amlodipine Design of Experiment (DOE) Biphasic recognition chiral extraction (BRCE) Access is limited to UniMAP community. The enantioselective extraction of (R)-amlodipine in a biphasic recognition chiral extraction (BRCE) system combining a hydrophobic L-tartrate in organic phase and hydrophilic β-cyclodextrin (β-CD) in aqueous phase has been studied. In this work, the process screening on temperature, pH, concentration of hydroxylpropyl-β-cyclodextrin (HP-β-CD), concentration of diethyl-L-tartrate and concentration of racemic amlodipine all exert a considerable influence on the biphasic recognition process. In order to plan the procedure of experiment, Design of Experiment (DOE), that is Fractional Factorial design is used for process screening purpose. Experimental results show that concentration of L-tartrate has affect the enantiomer separation of amlodipine drug. The most significant effects were temperature, pH, concentration of HP-β-CD and concentration of racemic amlodipine. In this study, distribution coefficient of (R)-amlodipine showed the highest value at 25˚C, pH 7, 0.05 mmol/L of racemic amlodipine and 0.05 mol/L of HP-β-CD. 2011-11-22T03:52:18Z 2011-11-22T03:52:18Z 2011-05 Learning Object http://hdl.handle.net/123456789/16156 en Universiti Malaysia Perlis School of Bioprocess Engineering
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic (R) - amlodipine
Design of Experiment (DOE)
Biphasic recognition chiral extraction (BRCE)
spellingShingle (R) - amlodipine
Design of Experiment (DOE)
Biphasic recognition chiral extraction (BRCE)
Ooi, Ai Chiaw
Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)
description Access is limited to UniMAP community.
author2 Hairul Nazirah Abdul Halim
author_facet Hairul Nazirah Abdul Halim
Ooi, Ai Chiaw
format Learning Object
author Ooi, Ai Chiaw
author_sort Ooi, Ai Chiaw
title Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)
title_short Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)
title_full Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)
title_fullStr Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)
title_full_unstemmed Process screening studies on enantioselective extraction of (R)-Amlodipine using design of experiment (DOE)
title_sort process screening studies on enantioselective extraction of (r)-amlodipine using design of experiment (doe)
publisher Universiti Malaysia Perlis
publishDate 2011
url http://dspace.unimap.edu.my/xmlui/handle/123456789/16156
_version_ 1643802717955555328
score 13.222552

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