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Computer-aided process design tools for debottlenecking a batch pharmaceutical production

Link to publisher's homepage at http://www.myiem.org.my/

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Main Authors: Tan, Jully, Foo, Dominic Chwan Yee, Dr., Sivakumar, Kumaresan, Dr., Ramlan, Abdul Aziz, Prof.
Other Authors: tanjully@ucsi.edu.my
Format: Article
Language:English
Published: The Institution of Engineers, Malaysia 2011
Subjects:
Batch processing
Debottlenecking
Modelling and optimisation
Pharmaceutical production
Throughput analysis
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/13626
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spelling my.unimap-136262011-09-04T00:56:31Z Computer-aided process design tools for debottlenecking a batch pharmaceutical production Tan, Jully Foo, Dominic Chwan Yee, Dr. Sivakumar, Kumaresan, Dr. Ramlan, Abdul Aziz, Prof. tanjully@ucsi.edu.my dominic.foo@nottingham.edu.my shiva@ums.edu.my ramlan@cepp.utm.my Batch processing Debottlenecking Modelling and optimisation Pharmaceutical production Throughput analysis Link to publisher's homepage at http://www.myiem.org.my/ The main objective of this work is to model and to debottleneck a batch pharmaceutical production with computer-aided process design (CAPD) and simulation tools. An eye drop production case study is firstly modelled based on a pharmaceutical production plant. Throughput analysis is next utilised to identify process bottlenecks that limit the increase of production and to evaluate different debottlenecking schemes. Scheme 1 considers an effort to maximise process throughput for a single batch operation, while Schemes 2 and 3 explore the possibility of minimising combined utilisation value of the process bottleneck. With the increase of batch throughput, installation of a new labelling process and the addition of an intermediate tank, Scheme 3 is identified as the debottlenecking scheme that achieves the increased production demand of 25%. 2011-09-04T00:56:31Z 2011-09-04T00:56:31Z 2008-12 Article The Journal of the Institution of Engineers, Malaysia, vol. 68(4), 2008, pages 30-37 0126-513X http://myiem.org.my/content/iem_journal_2008-179.aspx http://hdl.handle.net/123456789/13626 en The Institution of Engineers, Malaysia
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Batch processing
Debottlenecking
Modelling and optimisation
Pharmaceutical production
Throughput analysis
spellingShingle Batch processing
Debottlenecking
Modelling and optimisation
Pharmaceutical production
Throughput analysis
Tan, Jully
Foo, Dominic Chwan Yee, Dr.
Sivakumar, Kumaresan, Dr.
Ramlan, Abdul Aziz, Prof.
Computer-aided process design tools for debottlenecking a batch pharmaceutical production
description Link to publisher's homepage at http://www.myiem.org.my/
author2 tanjully@ucsi.edu.my
author_facet tanjully@ucsi.edu.my
Tan, Jully
Foo, Dominic Chwan Yee, Dr.
Sivakumar, Kumaresan, Dr.
Ramlan, Abdul Aziz, Prof.
format Article
author Tan, Jully
Foo, Dominic Chwan Yee, Dr.
Sivakumar, Kumaresan, Dr.
Ramlan, Abdul Aziz, Prof.
author_sort Tan, Jully
title Computer-aided process design tools for debottlenecking a batch pharmaceutical production
title_short Computer-aided process design tools for debottlenecking a batch pharmaceutical production
title_full Computer-aided process design tools for debottlenecking a batch pharmaceutical production
title_fullStr Computer-aided process design tools for debottlenecking a batch pharmaceutical production
title_full_unstemmed Computer-aided process design tools for debottlenecking a batch pharmaceutical production
title_sort computer-aided process design tools for debottlenecking a batch pharmaceutical production
publisher The Institution of Engineers, Malaysia
publishDate 2011
url http://dspace.unimap.edu.my/xmlui/handle/123456789/13626
_version_ 1643790941633380352
score 13.222552

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