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Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection

Link to publisher's homepage at http://www.groupes.polymtl.ca/jnmes/

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Main Authors: T.S., Dhahi, Uda, Hashim, Prof. Dr., N.M., Ahmed, H., Nazma
Format: Article
Language:English
Published: Journal of New Materials for Electrochemical Systems 2011
Subjects:
Nano-gap
Biosensor
DNA
Gold electrode
Hybridization
Immobilization
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/13306
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spelling my.unimap-133062016-06-12T14:47:06Z Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection T.S., Dhahi Uda, Hashim, Prof. Dr. N.M., Ahmed H., Nazma Nano-gap Biosensor DNA Gold electrode Hybridization Immobilization Link to publisher's homepage at http://www.groupes.polymtl.ca/jnmes/ We develop a method for fabricating the nano-gaps directly by using just photolithography and wet etching processes without any nano lithography or difficult techniques. It shows that this resolution enhancement allows one to fabricate metal electrodes with separation from arbitrarily large to fewer than one hundred nanometers. Furthermore, because these nano-gaps are on a thin film, they can be imaged with high-resolution transmission electron microscopy (HRTEM). Efforts toward achieving electrical contact to nanostructures have been active for over a decade. Even though several devices based on "nano-gaps" - two gaps separated by a nanometer-scale distance - have been demonstrated, their realization has remained a significant challenge. Even the best methods are highly labor-intensive and suffer from low yield and poor geometrical control. Most nano-gaps are also incompatible with high resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM). As a consequence, the proof of the nano-gap quality and content in past studies has been indirect. High-resolution imaging is therefore required to ensure the quality of nano-gaps and to be able to identify possible artifacts. This project presents a unique vertical nano-gap biosensor that can detect changes in DNA structure. Using a size reduction to interrogate samples between the nano-scale gaps, this biosensor will be sensitive enough to record the conformational changes for ss- DNA. 2011-07-22T01:28:16Z 2011-07-22T01:28:16Z 2011 Article Journal of New Materials for Electrochemical Systems, Vol. 14(3), 2011, pages 191-196 1480-2422 http://www.groupes.polymtl.ca/jnmes/modules/journal/index.php/content0296.html http://hdl.handle.net/123456789/13306 en Journal of New Materials for Electrochemical Systems
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Nano-gap
Biosensor
DNA
Gold electrode
Hybridization
Immobilization
spellingShingle Nano-gap
Biosensor
DNA
Gold electrode
Hybridization
Immobilization
T.S., Dhahi
Uda, Hashim, Prof. Dr.
N.M., Ahmed
H., Nazma
Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
description Link to publisher's homepage at http://www.groupes.polymtl.ca/jnmes/
format Article
author T.S., Dhahi
Uda, Hashim, Prof. Dr.
N.M., Ahmed
H., Nazma
author_facet T.S., Dhahi
Uda, Hashim, Prof. Dr.
N.M., Ahmed
H., Nazma
author_sort T.S., Dhahi
title Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
title_short Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
title_full Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
title_fullStr Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
title_full_unstemmed Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
title_sort fabrication and characterization of gold nano-gaps for ssdna immobilization and hybridization detection
publisher Journal of New Materials for Electrochemical Systems
publishDate 2011
url http://dspace.unimap.edu.my/xmlui/handle/123456789/13306
_version_ 1643790811628830720
score 13.209306

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