The role of interleukin-8 in inflammatory responses of fish
Interleukin-8, a novel chemotactic cytokine, has been shown to play an important role in activation and recruitment of neutrophils, and thus acts as a traffic controller. This study builds upon the breakthrough in cloning several fish cytokine genes including IL-8. The predicted rainbow trout Oncorh...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
Scotland, United Kingdom: University of Aberdeen
2013
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| Subjects: | |
| Online Access: | http://dspace.psnz.umt.edu.my/xmlui/handle/123456789/2723 |
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| Summary: | Interleukin-8, a novel chemotactic cytokine, has been shown to play an important role in activation and recruitment of neutrophils, and thus acts as a traffic controller. This study builds upon the breakthrough in cloning several fish cytokine genes including IL-8. The predicted rainbow trout Oncorhynchus mykiss mature interleukin-8 peptide has been produced as a recombinant protein in E. coli; interleukin-8 (riL-8a) and a
mutated form lacking a receptor binding motif (riL-8b) were studied initially in vitro and in vivo. |
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