Preparation, optimisation, and in vitro evaluation of [¹⁸F] AlF-NOTA-Pamidronic acid for bone imaging PET

• Main Authors: Hishar Hassan, Muhamad Faiz Othman, Hairil Rashmizal Abdul Razak, Zainul Amiruddin Zakaria, Fathinul Fikri Ahmad Saad, Mohd Azuraidi Osman, Loh, Hui Yi, Zarif Ashhar, Jaleezah Idris, Mohd Hamdi Noor Abdul Hamid, Zaitulhusna M. Safee
• Format: Article
• Language: English; English
• Published: Molecular Diversity Preservation International 2022
• Subjects: R5-920 Medicine (General); RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
• Online Access: https://eprints.ums.edu.my/id/eprint/42277/1/ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/42277/2/FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/42277/; https://doi.org/10.3390/molecules27227969

[¹⁸F] sodium fluoride ([¹⁸F] NaF) is recognised to be superior to [⁹⁹mTc]-methyl diphosphate ([⁹⁹mTc]Tc-MDP) and 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) in bone imaging. However, there is concern that [¹⁸F] NaF uptake is not cancer-specific, leading to a higher number of false-positive interpreta...