An In Silico Design of Peptides Targeting the S1/S2 Cleavage Site of the SARS-CoV-2 Spike Protein

• Main Authors: Chian Ho, Wan Fahmi Wan Mohamad Nazarie, Lee, Ping Chin
• Format: Article
• Language: English; English
• Published: MDPI 2023
• Subjects: RA643-645 Disease (Communicable and noninfectious) and public health
• Online Access: https://eprints.ums.edu.my/id/eprint/37729/1/ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/37729/2/FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/37729/; https://doi.org/10.3390/v15091930

SARS-CoV-2, responsible for the COVID-19 pandemic, invades host cells via its spike protein, which includes critical binding regions, such as the receptor-binding domain (RBD), the S1/S2 cleavage site, the S2 cleavage site, and heptad-repeat (HR) sections. Peptides targeting the RBD and HR1 inhibit...