Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery
Coronavirus disease (COVID-19) has killed millions of people since first reported in Wuhan, China, in December 2019. Intriguingly, Withania somnifera (WS) has shown promising antiviral effects against numerous viral infections, including SARS-CoV and SARS-CoV-2, which are contributed by its phytoche...
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Molecular Diversity Preservation International (MDPI)
2023
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Online Access: | https://eprints.ums.edu.my/id/eprint/36298/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36298/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/36298/ https://doi.org/10.3390/microorganisms11041000 |
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my.ums.eprints.362982023-08-07T08:02:40Z https://eprints.ums.edu.my/id/eprint/36298/ Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery Suaidah Ramli Yuan Seng Wu Kalaivani Batumalaie Rhanye Mac Guad Ker Woon Choy Ashok Kumar Subash C. B. Gopinath Md. Moklesur Rahman Sarker Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Suresh V. Chinni Gobinath Ramachawolran RA643-645 Disease (Communicable and noninfectious) and public health RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Coronavirus disease (COVID-19) has killed millions of people since first reported in Wuhan, China, in December 2019. Intriguingly, Withania somnifera (WS) has shown promising antiviral effects against numerous viral infections, including SARS-CoV and SARS-CoV-2, which are contributed by its phytochemicals. This review focused on the updated testing of therapeutic efficacy and associated molecular mechanisms of WS extracts and their phytochemicals against SARS-CoV-2 infection in preclinical and clinical studies with the aim to develop a long-term solution against COVID-19. Italso deciphered the current use of the in silico molecular docking approach in developing potential inhibitors from WS targeting SARS-CoV-2 and host cell receptors that may aid the development of targeted therapy against SARS-CoV-2 ranging from prior to viral entry until acute respiratory distress syndrome (ARDS). This review also discussed nanoformulations or nanocarriers in achieving effective WS delivery to enhance its bioavailability and therapeutic efficacy, consequently preventing the emergence of drug resistance, and eventually therapeutic failure. Molecular Diversity Preservation International (MDPI) 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/36298/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/36298/2/FULL%20TEXT.pdf Suaidah Ramli and Yuan Seng Wu and Kalaivani Batumalaie and Rhanye Mac Guad and Ker Woon Choy and Ashok Kumar and Subash C. B. Gopinath and Md. Moklesur Rahman Sarker and Vetriselvan Subramaniyan and Mahendran Sekar and Neeraj Kumar Fuloria and Shivkanya Fuloria and Suresh V. Chinni and Gobinath Ramachawolran (2023) Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery. Microorganisms, 11. pp. 1-26. https://doi.org/10.3390/microorganisms11041000 |
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RA643-645 Disease (Communicable and noninfectious) and public health RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Suaidah Ramli Yuan Seng Wu Kalaivani Batumalaie Rhanye Mac Guad Ker Woon Choy Ashok Kumar Subash C. B. Gopinath Md. Moklesur Rahman Sarker Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Suresh V. Chinni Gobinath Ramachawolran Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery |
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Coronavirus disease (COVID-19) has killed millions of people since first reported in Wuhan, China, in December 2019. Intriguingly, Withania somnifera (WS) has shown promising antiviral effects against numerous viral infections, including SARS-CoV and SARS-CoV-2, which are contributed by its phytochemicals. This review focused on the updated testing of therapeutic efficacy and associated molecular mechanisms of WS extracts and their phytochemicals against SARS-CoV-2 infection in preclinical and clinical studies with the aim to develop a long-term solution against COVID-19. Italso deciphered the current use of the in silico molecular docking approach in developing potential inhibitors from WS targeting SARS-CoV-2 and host cell receptors that may aid the development of targeted therapy against SARS-CoV-2 ranging from prior to viral entry until acute respiratory distress syndrome (ARDS). This review also discussed nanoformulations or nanocarriers in achieving effective WS delivery to enhance its bioavailability and therapeutic efficacy, consequently preventing the emergence of drug resistance, and eventually therapeutic failure. |
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author |
Suaidah Ramli Yuan Seng Wu Kalaivani Batumalaie Rhanye Mac Guad Ker Woon Choy Ashok Kumar Subash C. B. Gopinath Md. Moklesur Rahman Sarker Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Suresh V. Chinni Gobinath Ramachawolran |
author_facet |
Suaidah Ramli Yuan Seng Wu Kalaivani Batumalaie Rhanye Mac Guad Ker Woon Choy Ashok Kumar Subash C. B. Gopinath Md. Moklesur Rahman Sarker Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Suresh V. Chinni Gobinath Ramachawolran |
author_sort |
Suaidah Ramli |
title |
Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery |
title_short |
Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery |
title_full |
Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery |
title_fullStr |
Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery |
title_full_unstemmed |
Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery |
title_sort |
phytochemicals of withania somnifera as a future promising drug against sars-cov-2: pharmacological role, molecular mechanism, molecular docking evaluation, and efficient delivery |
publisher |
Molecular Diversity Preservation International (MDPI) |
publishDate |
2023 |
url |
https://eprints.ums.edu.my/id/eprint/36298/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36298/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/36298/ https://doi.org/10.3390/microorganisms11041000 |
_version_ |
1775623856221847552 |
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13.160551 |