A novel Pseudorabies virus vaccine developed using HDR-CRISPR/Cas9 induces strong humoral and cellular immune response in mice

• Main Authors: Chen Luo, Qianqian Wang, Ruhai Guo, Jingnan Zhang, Jingya Zhang, Riteng Zhang, Xin Ma, Peixin Wang, Fathalrhman Eisa Addoma Adam, Basit Zeshan, Zengqi Yang, Yefei Zhou, Xinglong Wang
• Format: Article
• Language: English; English
• Published: Elsevier B.V. 2022
• Subjects: RA638 Immunity and immunization in relation to public health; SF1-1100 Animal culture
• Online Access: https://eprints.ums.edu.my/id/eprint/34792/1/Abstract.pdf; https://eprints.ums.edu.my/id/eprint/34792/2/Full%20text.pdf; https://eprints.ums.edu.my/id/eprint/34792/; https://www.sciencedirect.com/science/article/abs/pii/S0168170222002659; https://doi.org/10.1016/j.virusres.2022.198937

Outbreaks of Pseudorabies (PR) by numerous highly virulent and antigenic variant Pseudorabies virus (PRV) strains have been causing severe economic losses to the pig industry in China since 2011. However, current commercial vaccines are often unable to induce thorough protective immunity. In this st...