Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

• Main Authors: Xuejun Fan, Zihao Yuan, Yueshui Zhao, Wei Xiong, Hsiao, Hao-Ching, Rahmawati Pare, Jianmin Ding, Ahmad Almosa, Kai Sun, Songlin Zhang, Jordan, Robert E., Cheok, Song Lee, Zhiqiang An, Ningyan Zhang
• Format: Article
• Language: English; English
• Published: Springer Nature 2022
• Subjects: RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
• Online Access: https://eprints.ums.edu.my/id/eprint/34647/2/FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/34647/1/ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/34647/; https://www.nature.com/articles/s42003-022-03931-7.pdf; https://doi.org/10.1038/s42003-022-03931-7

Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about...