Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers
Southeast Asia comprises 11 countries that span mainland Asia across to numerous islands that stretch from the Andaman Sea to the South China Sea and Indian Ocean. This region harbors an impressive diversity of history, culture, religion and biology. Indigenous people of Malaysia display substantial...
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my.ums.eprints.343372022-09-29T03:41:28Z https://eprints.ums.edu.my/id/eprint/34337/ Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers Farhang Aghakhanian Hoh, Boon‑Peng Yew, Chee Wei Vijay Kumar Subbiah Yali Xue ChrisTyler‑Smith Qasim Ayub Maude E. Phipps DS591-599 Malaysia. Malay Peninsula. Straits Settlements QH426-470 Genetics Southeast Asia comprises 11 countries that span mainland Asia across to numerous islands that stretch from the Andaman Sea to the South China Sea and Indian Ocean. This region harbors an impressive diversity of history, culture, religion and biology. Indigenous people of Malaysia display substantial phenotypic, linguistic, and anthropological diversity. Despite this remarkable diversity which has been documented for centuries, the genetic history and structure of indigenous Malaysians remain under-studied. To have a better understanding about the genetic history of these people, especially Malaysian Negritos, we sequenced whole genomes of 15 individuals belonging to five indigenous groups from Peninsular Malaysia and one from North Borneo to high coverage (30X). Our results demonstrate that indigenous populations of Malaysia are genetically close to East Asian populations. We show that present-day Malaysian Negritos can be modeled as an admixture of ancient Hoabinhian hunter-gatherers and Neolithic farmers. We observe gene flow from South Asian populations into the Malaysian indigenous groups, but not into Dusun of North Borneo. Our study proposes that Malaysian indigenous people originated from at least three distinct ancestral populations related to the Hoabinhian hunter-gatherers, Neolithic farmers and Austronesian speakers. Springer Nature Limited 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34337/1/Abstract.pdf text en https://eprints.ums.edu.my/id/eprint/34337/2/Full%20text.pdf Farhang Aghakhanian and Hoh, Boon‑Peng and Yew, Chee Wei and Vijay Kumar Subbiah and Yali Xue and ChrisTyler‑Smith and Qasim Ayub and Maude E. Phipps (2022) Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers. Scientific reports, 12 (13743). pp. 1-11. ISSN 2045-2322 https://www.nature.com/articles/s41598-022-17884-8 https://doi.org/10.1038/s41598-022-17884-8 |
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DS591-599 Malaysia. Malay Peninsula. Straits Settlements QH426-470 Genetics Farhang Aghakhanian Hoh, Boon‑Peng Yew, Chee Wei Vijay Kumar Subbiah Yali Xue ChrisTyler‑Smith Qasim Ayub Maude E. Phipps Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers |
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Southeast Asia comprises 11 countries that span mainland Asia across to numerous islands that stretch from the Andaman Sea to the South China Sea and Indian Ocean. This region harbors an impressive diversity of history, culture, religion and biology. Indigenous people of Malaysia display substantial phenotypic, linguistic, and anthropological diversity. Despite this remarkable diversity which has been documented for centuries, the genetic history and structure of indigenous Malaysians remain under-studied. To have a better understanding about the genetic history of these people, especially Malaysian Negritos, we sequenced whole genomes of 15 individuals belonging to five indigenous groups from Peninsular Malaysia and one from North Borneo to high coverage (30X). Our results demonstrate that indigenous populations of Malaysia are genetically close to East Asian populations. We show that present-day Malaysian Negritos can be modeled as an admixture of ancient Hoabinhian hunter-gatherers and Neolithic farmers. We observe gene flow from South Asian populations into the Malaysian indigenous groups, but not into Dusun of North Borneo. Our study proposes that Malaysian indigenous people originated from at least three distinct ancestral populations related to the Hoabinhian hunter-gatherers, Neolithic farmers and Austronesian speakers. |
format |
Article |
author |
Farhang Aghakhanian Hoh, Boon‑Peng Yew, Chee Wei Vijay Kumar Subbiah Yali Xue ChrisTyler‑Smith Qasim Ayub Maude E. Phipps |
author_facet |
Farhang Aghakhanian Hoh, Boon‑Peng Yew, Chee Wei Vijay Kumar Subbiah Yali Xue ChrisTyler‑Smith Qasim Ayub Maude E. Phipps |
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Farhang Aghakhanian |
title |
Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers |
title_short |
Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers |
title_full |
Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers |
title_fullStr |
Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers |
title_full_unstemmed |
Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers |
title_sort |
sequence analyses of malaysian indigenous communities reveal historical admixture between hoabinhian hunter-gatherers and neolithic farmers |
publisher |
Springer Nature Limited |
publishDate |
2022 |
url |
https://eprints.ums.edu.my/id/eprint/34337/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/34337/2/Full%20text.pdf https://eprints.ums.edu.my/id/eprint/34337/ https://www.nature.com/articles/s41598-022-17884-8 https://doi.org/10.1038/s41598-022-17884-8 |
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1760231281835114496 |
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13.160551 |