Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review
Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing sign...
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my.ums.eprints.334482022-07-21T04:06:49Z https://eprints.ums.edu.my/id/eprint/33448/ Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review Tay, Kai Xin Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Win, Win Than Abdel Mohsen Mohamed Ahmed Abdel Hafez RG500-991 Obstetrics Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing significant damage to the basement membrane of the skin, resulting in marked pruritus and blisters on the abdomen and extremities. Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies and histopathology of a skin biopsy. Treatment, just as for other autoimmune dermatoses, is achieved by corticosteroids with the risk of relapses in subsequent pregnancies. Fetal growth restriction and pre-maturity are potential fetal complications associated with the disease, hence the recommended combined antenatal care by a dermatologist as well as an obstetrician, however, this disease is unlikely to be a source of significant maternal morbidity or mortality. Elsevier 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33448/1/Pemphigoid%20Gestationis%20and%20adverse%20pregnancy%20outcomes.pdf text en https://eprints.ums.edu.my/id/eprint/33448/2/Pemphigoid%20Gestationis%20and%20adverse%20pregnancy%20outcomes%20_ABSTRACT.pdf Tay, Kai Xin and Mohd Firdaus Mohd Hayati and Fairrul Masnah @ Kadir and Win, Win Than and Abdel Mohsen Mohamed Ahmed Abdel Hafez (2022) Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review. Journal of Gynecology Obstetrics and Human Reproduction, 51 (102370). pp. 1-8. ISSN 2468-7847 https://www.sciencedirect.com/science/article/pii/S2468784722000617?casa_token=StvxipNy5ZgAAAAA:yzz4mJlL8Ef59l3_xZ0AL8CufC66inWXlERT3amEKZNCCt6tgsfewTv59NyW7LOMd6ai9t-3y7E https://doi.org/10.1016/j.jogoh.2022.102370 |
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Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing significant damage to the basement membrane of the skin, resulting in marked pruritus and blisters on the abdomen and extremities. Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies and histopathology of a skin biopsy. Treatment, just as for other autoimmune dermatoses, is achieved by corticosteroids with the risk of relapses in subsequent pregnancies. Fetal growth restriction and pre-maturity are potential fetal complications associated with the disease, hence the recommended combined antenatal care by a dermatologist as well as an obstetrician, however, this disease is unlikely to be a source of significant maternal morbidity or mortality. |
format |
Article |
author |
Tay, Kai Xin Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Win, Win Than Abdel Mohsen Mohamed Ahmed Abdel Hafez |
author_facet |
Tay, Kai Xin Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Win, Win Than Abdel Mohsen Mohamed Ahmed Abdel Hafez |
author_sort |
Tay, Kai Xin |
title |
Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review |
title_short |
Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review |
title_full |
Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review |
title_fullStr |
Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review |
title_full_unstemmed |
Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review |
title_sort |
pemphigoid gestationis and adverse pregnancy outcomes: a literature review |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://eprints.ums.edu.my/id/eprint/33448/1/Pemphigoid%20Gestationis%20and%20adverse%20pregnancy%20outcomes.pdf https://eprints.ums.edu.my/id/eprint/33448/2/Pemphigoid%20Gestationis%20and%20adverse%20pregnancy%20outcomes%20_ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/33448/ https://www.sciencedirect.com/science/article/pii/S2468784722000617?casa_token=StvxipNy5ZgAAAAA:yzz4mJlL8Ef59l3_xZ0AL8CufC66inWXlERT3amEKZNCCt6tgsfewTv59NyW7LOMd6ai9t-3y7E https://doi.org/10.1016/j.jogoh.2022.102370 |
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