Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer

• Main Authors: Manzar Alam, Shoaib Alam, Anas Shamsi, Mohd Adnan, Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Mousa Alreshidi, Yousef MohammedRabaa Hawsawi, Anitha Tippana, Pasupuleti Visweswara Rao, Md. Imtaiyaz Hassan
• Format: Article
• Language: English; English
• Published: Frontiers Media SA 2022
• Subjects: RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
• Online Access: https://eprints.ums.edu.my/id/eprint/33339/1/Bax.pdf; https://eprints.ums.edu.my/id/eprint/33339/2/Bax1.pdf; https://eprints.ums.edu.my/id/eprint/33339/; https://www.frontiersin.org/articles/10.3389/fonc.2022.869672/full; http://dx.doi.org/10.3389/fonc.2022.869672

Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR is involved in several cancer developments, including NSCLC. The EGFR pathway regulates the Bax/Bcl-2 cascade in NSCLC. Increasing understanding of the molecular mechanisms of fundamental tumor progression has guided...