Effect of Kelulut honey supplementation on bone health in male rats on high-carbohydrate high-fat diet
Purpose: To determine the effects of Kelulut honey (KH) on the bone health of rats with metabolic syndrome. Methods: Male Wistar rats were randomized into normal control and metabolic syndrome s fed with a diet enriched with carbohydrate and fat. The rats in the metabolic syndrome arm were further a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
University of Benin
2021
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/31835/1/Effect%20of%20Kelulut%20honey%20supplementation%20on%20bone%20health%20in%20male%20rats%20on%20high-carbohydrate%20high-fat%20diet.pdf https://eprints.ums.edu.my/id/eprint/31835/2/Effect%20of%20Kelulut%20honey%20supplementation%20on%20bone%20health%20in%20male%20rats%20on%20high-carbohydrate%20high-fat%20diet1.pdf https://eprints.ums.edu.my/id/eprint/31835/ https://www.ajol.info/index.php/tjpr/article/view/221033 http://dx.doi.org/10.4314/tjpr.v20i6.13 |
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| Summary: | Purpose: To determine the effects of Kelulut honey (KH) on the bone health of rats with metabolic syndrome. Methods: Male Wistar rats were randomized into normal control and metabolic syndrome s fed with a diet enriched with carbohydrate and fat. The rats in the metabolic syndrome arm were further assigned into the negative control group and honey group supplemented orally with Kelulut honey (1g/kg) daily for eight weeks. After the rats were sacrificed, the trabecular and cortical micro-architecture of the harvested femur was analysed using X-ray micro-computed tomography, while histomorphometric method was used to determine bone cell indices. Femoral biomechanical properties were analysed using a universal mechanical tester. Results: Total cross-sectional area, osteoid surface and volume, displacement and strain reduced significantly, while eroded surface increased significantly in the rats with metabolic syndrome than the normal rats (p < 0.05). The honey group showed a significant reduction in osteoclast surface than the normal healthy control (p < 0.05). Other skeletal parameters did not show a significant intergroup difference. Conclusion: Metabolic syndrome is harmful to bone health and honey has limited effects in reversing these negative effects. |
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