Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia
Background The simian malaria parasite Plasmodium knowlesi is emerging as a public health problem in Southeast Asia, particularly in Malaysian Borneo where it now accounts for the greatest burden of malaria cases and deaths. Control is hindered by limited understanding of the ecology of potential ve...
Saved in:
id |
my.ums.eprints.30181 |
---|---|
record_format |
eprints |
spelling |
my.ums.eprints.301812021-07-31T03:50:12Z https://eprints.ums.edu.my/id/eprint/30181/ Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia Meng L. Wong Chua, Tock Hing Cherng S. Leong Loke T. Khaw Kimberly Fornace Wan Yusoff Wan Sulaiman Timothy William Chris Drakeley Heather M. Ferguson Indra Vythilingam R Medicine (General) RA Public aspects of medicine Background The simian malaria parasite Plasmodium knowlesi is emerging as a public health problem in Southeast Asia, particularly in Malaysian Borneo where it now accounts for the greatest burden of malaria cases and deaths. Control is hindered by limited understanding of the ecology of potential vector species. Methodology/Principal Findings We conducted a one-year longitudinal study of P. knowlesi vectors in three sites within an endemic area of Sabah, Malaysia. All mosquitoes were captured using human landing catch. Anopheles mosquitoes were dissected to determine, oocyst, sporozoites and parous rate. Anopheles balabacensis is confirmed as the primary vector of. P. knowlesi (using nested PCR) in Sabah for the first time. Vector densities were significantly higher and more seasonally variable in the village than forest or small-scale farming site. However, An. balabacensis survival and P. knowlesi infection rates were highest in forest and small-scale farm sites. Anopheles balabacensis mostly bites humans outdoors in the early evening between 1800 to 2000hrs. Conclusions/Significance This study indicates transmission is unlikely to be prevented by bednets. This combined with its high vectorial capacity poses a threat to malaria elimination programmes within the region. PLOS Neglected Tropical Diseases 2015 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/30181/1/Seasonal%20and%20spatial%20dynamics%20of%20the%20primary%20vector%20of%20plasmodium%20knowlesi%20within%20a%20major%20transmission%20focus%20in%20Sabah%2C%20Malaysia.pdf text en https://eprints.ums.edu.my/id/eprint/30181/2/Seasonal%20and%20spatial%20dynamics%20of%20the%20primary%20vector%20of%20plasmodium%20knowlesi%20within%20a%20major%20transmission%20focus%20in%20Sabah%2C%20Malaysia1.pdf Meng L. Wong and Chua, Tock Hing and Cherng S. Leong and Loke T. Khaw and Kimberly Fornace and Wan Yusoff Wan Sulaiman and Timothy William and Chris Drakeley and Heather M. Ferguson and Indra Vythilingam (2015) Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia. PLOS Neglected Tropical Diseases, 9. pp. 1-15. ISSN 1935-2735 https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0004135/1/pntd.0004135.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210730%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210730T131554Z&X-Goog-Expires=86400&X-Goog-SignedHeaders=host&X-Goog-Signature=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 https://doi.org/10.1371/journal.pntd.0004135 |
institution |
Universiti Malaysia Sabah |
building |
UMS Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaysia Sabah |
content_source |
UMS Institutional Repository |
url_provider |
http://eprints.ums.edu.my/ |
language |
English English |
topic |
R Medicine (General) RA Public aspects of medicine |
spellingShingle |
R Medicine (General) RA Public aspects of medicine Meng L. Wong Chua, Tock Hing Cherng S. Leong Loke T. Khaw Kimberly Fornace Wan Yusoff Wan Sulaiman Timothy William Chris Drakeley Heather M. Ferguson Indra Vythilingam Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia |
description |
Background The simian malaria parasite Plasmodium knowlesi is emerging as a public health problem in Southeast Asia, particularly in Malaysian Borneo where it now accounts for the greatest burden of malaria cases and deaths. Control is hindered by limited understanding of the ecology of potential vector species. Methodology/Principal Findings We conducted a one-year longitudinal study of P. knowlesi vectors in three sites within an endemic area of Sabah, Malaysia. All mosquitoes were captured using human landing catch. Anopheles mosquitoes were dissected to determine, oocyst, sporozoites and parous rate. Anopheles balabacensis is confirmed as the primary vector of. P. knowlesi (using nested PCR) in Sabah for the first time. Vector densities were significantly higher and more seasonally variable in the village than forest or small-scale farming site. However, An. balabacensis survival and P. knowlesi infection rates were highest in forest and small-scale farm sites. Anopheles balabacensis mostly bites humans outdoors in the early evening between 1800 to 2000hrs. Conclusions/Significance This study indicates transmission is unlikely to be prevented by bednets. This combined with its high vectorial capacity poses a threat to malaria elimination programmes within the region. |
format |
Article |
author |
Meng L. Wong Chua, Tock Hing Cherng S. Leong Loke T. Khaw Kimberly Fornace Wan Yusoff Wan Sulaiman Timothy William Chris Drakeley Heather M. Ferguson Indra Vythilingam |
author_facet |
Meng L. Wong Chua, Tock Hing Cherng S. Leong Loke T. Khaw Kimberly Fornace Wan Yusoff Wan Sulaiman Timothy William Chris Drakeley Heather M. Ferguson Indra Vythilingam |
author_sort |
Meng L. Wong |
title |
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia |
title_short |
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia |
title_full |
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia |
title_fullStr |
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia |
title_full_unstemmed |
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia |
title_sort |
seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in sabah, malaysia |
publisher |
PLOS Neglected Tropical Diseases |
publishDate |
2015 |
url |
https://eprints.ums.edu.my/id/eprint/30181/1/Seasonal%20and%20spatial%20dynamics%20of%20the%20primary%20vector%20of%20plasmodium%20knowlesi%20within%20a%20major%20transmission%20focus%20in%20Sabah%2C%20Malaysia.pdf https://eprints.ums.edu.my/id/eprint/30181/2/Seasonal%20and%20spatial%20dynamics%20of%20the%20primary%20vector%20of%20plasmodium%20knowlesi%20within%20a%20major%20transmission%20focus%20in%20Sabah%2C%20Malaysia1.pdf https://eprints.ums.edu.my/id/eprint/30181/ https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0004135/1/pntd.0004135.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210730%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210730T131554Z&X-Goog-Expires=86400&X-Goog-SignedHeaders=host&X-Goog-Signature=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 https://doi.org/10.1371/journal.pntd.0004135 |
_version_ |
1760230729013264384 |
score |
13.160551 |