Critical involvement of pneumolysin in production of interleukin-1 alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation

• Main Authors: Shereen Shoma, Kohsuke Tsuchiya, Ikuo Kawamura, Takamasa Nomura, Hideki Hara, Ryosuke Uchiyama, Sylvia Daim, Masao Mitsuyama
• Format: Article
• Language: English; English
• Published: American Society for Microbiology 2008
• Subjects: R5-920 Medicine (General)
• Online Access: https://eprints.ums.edu.my/id/eprint/29305/1/Critical%20involvement%20of%20pneumolysin%20in%20production%20of%20interleukin-1%CE%B1%20and%20caspase-1-dependent%20cytokines%20in%20infection%20with%20streptococcus%20pneumoniae%20in%20vitro.pdf; https://eprints.ums.edu.my/id/eprint/29305/2/Critical%20involvement%20of%20pneumolysin%20in%20production%20of%20interleukin-1%CE%B1%20and%20caspase-1-dependent%20cytokines%20in%20infection%20with%20streptococcus%20pneumoniae%20in%20vitro1.pdf; https://eprints.ums.edu.my/id/eprint/29305/; http://iai.asm.org/content/76/4/1547.full; https://doi.org/10.1128/IAI.01269-07

Pneumolysin is a pore-forming cytolysin known as a major virulence determinant of Streptococcus pneumoniae. This protein toxin has also been shown to activate the Toll-like receptor 4 (TLR4) signaling pathway. In this study, a mutant S. pneumoniae strain deficient in pneumolysin (Δply) and a recombi...