Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives

• Main Authors: Suri Babu Patchipala, Pasupuleti Visweswara Rao, Amrutha V Audipudi, Hari babu Bollikolla
• Format: Article
• Language: English; English
• Published: Elsevier 2022
• Subjects: RC31-1245 Internal medicine
• Online Access: https://eprints.ums.edu.my/id/eprint/28959/2/Synthesis%2C%20in-vivo%20anti-diabetic%20%26%20anticancer%20activities%20and%20molecular%20modelling%20studies%20of%20tetrahydrobenzo%5Bd%5Dthiazole%20tethered%20nicotinohydrazide%20derivatives.pdf; https://eprints.ums.edu.my/id/eprint/28959/3/Synthesis%2C%20in-vivo%20anti-diabetic%20%26%20anticancer%20activities%20and%20molecular%20modelling%20studies%20of%20tetrahydrobenzo%5Bd%5Dthiazole%20tethered%20nicotinohydrazide%20derivatives%20_ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/28959/; https://www.sciencedirect.com/science/article/pii/S187853522100561X; https://doi.org/10.1016/j.arabjc.2021.103546

A series of thirty new thiazole-pyridine derivatives were synthesized by reaction of 4,4,7,7-tetra-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine with 6-chloronicotinate followed by condensing with benzaldehydes and screened for their anti-diabetic activity by in vivo housing Swiss albino mice. Al...