Engineered mycobacterium tuberculosis antigen assembly into core-shell nanobeads for diagnosis of tuberculosis

• Main Authors: Nurul Syahidah Sheffee, Patricia Rubio-Reyes, Mayelin Mirabal, Romel Calero, Humberto Carrillo-Calvet, Shuxiong Chen, Chin, Kai Ling, Nur Atiqah Syairah Shakimi, Fadhilah Zulkipli Anis, Siti Suraiya, Maria E. Sarmiento, Mohd Nor Norazmi, Armando Acosta, Bernd H.A. Rehm
• Format: Article
• Language: English; English
• Published: Elsevier Inc. 2021
• Subjects: R Medicine (General); RB Pathology
• Online Access: https://eprints.ums.edu.my/id/eprint/27284/1/Engineered%20mycobacterium%20tuberculosis%20antigen%20assembly%20into%20core-shell%20nanobeads%20for%20diagnosis%20of%20tuberculosis%20FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/27284/2/Engineered%20mycobacterium%20tuberculosis%20antigen%20assembly%20into%20core-shell%20nanobeads%20for%20diagnosis%20of%20tuberculosis%20ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/27284/; https://www.sciencedirect.com/science/article/pii/S1549963421000174?casa_token=yBNTAZGBt94AAAAA:Aipr5TiGUOFLKAXcA3uQqhAV9k3zp0K6FL6BkT62LH1Tsd-VrV2aRZvj6j959onYWFhKQOdId-Ml

Despite recent advances in diagnosis, tuberculosis (TB) remains one of the ten leading causes of death worldwide. Here, we engineered Mycobacterium tuberculosis (Mtb) proteins (ESAT6, CFP10, and MTB7.7) to self-assemble into core-shell nanobeads for enhanced TB diagnosis. Respective purified Mtb ant...