Aqueous leaf extract of Clinacanthus nutans inhibits growth and induces apoptosis via the intrinsic and extrinsic pathways in MDA-MB-231 human breast cancer cells

• Main Authors: Marilyn Jane Yong, Ahmad Zaidi Tani, Falah Abass Mohamed Salih, Rahmawati Pare, Rina Norgainathai, Fong, Siat Yee
• Format: Article
• Language: English; English
• Published: Wolters Kluwer - Medknow 2021
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: https://eprints.ums.edu.my/id/eprint/26902/1/Aqueous%20leaf%20extract%20of%20Clinacanthus%20nutans%20inhibits%20growth%20and%20induces%20apoptosis%20via%20the%20intrinsic%20and%20extrinsic%20pathways%20in%20MDA-MB-231%20human%20breast%20cancer%20cells.pdf; https://eprints.ums.edu.my/id/eprint/26902/2/Aqueous%20leaf%20extract%20of%20Clinacanthus%20nutans%20inhibits%20growth%20and%20induces%20apoptosis%20via%20the%20intrinsic%20and%20extrinsic%20pathways%20in%20MDA-MB-231%20human%20breast%20cancer%20cells1.pdf; https://eprints.ums.edu.my/id/eprint/26902/; https://www.phcog.com/article.asp?issn=0973-1296;year=2020;volume=16;issue=72;spage=689;epage=694;aulast=Yong

Background: Clinacanthus nutans possesses several reported biological activities against different human cancer cells. However, reports on the growth-inhibitory effect of C. nutans leaf extract on the aggressive triple-negative breast cancer cells and the mechanisms of induced-cell death in these ce...