Gliosarcoma of a Brain: A Challenging Diagnosis
Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was c...
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my.ums.eprints.264802020-12-17T07:34:58Z https://eprints.ums.edu.my/id/eprint/26480/ Gliosarcoma of a Brain: A Challenging Diagnosis Nornazirah Azizan Nor Haizura Ab Rani Ahmad Toha Samsudin Fadhli Mustaffa Firdaus Hayati R Medicine (General) Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was consistent with anaplastic convexity meningioma which was identical via intraoperative findings. However, the final histology revealed gliosarcoma of the brain. He recovered well postoperatively without any neurological deficit and had completed adjuvant chemoradiotherapy. He was asymptomatic during follow up with no tumour recurrence. Gliosarcoma with predominant sarcomatous component mimicking a meningioma has prolonged survival as compared to a case with predominant glioblastoma component. Hence, the discordance between clinical, radiological, intraoperative and histopathological findings is a challenge in establishing a diagnosis of gliosarcoma. 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/26480/1/Gliosarcoma%20of%20a%20Brain.pdf text en https://eprints.ums.edu.my/id/eprint/26480/2/Gliosarcoma%20of%20a%20Brain1.pdf Nornazirah Azizan and Nor Haizura Ab Rani and Ahmad Toha Samsudin and Fadhli Mustaffa and Firdaus Hayati (2020) Gliosarcoma of a Brain: A Challenging Diagnosis. Borneo Journal of Medical Sciences, 14 (3). pp. 39-44. |
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R Medicine (General) Nornazirah Azizan Nor Haizura Ab Rani Ahmad Toha Samsudin Fadhli Mustaffa Firdaus Hayati Gliosarcoma of a Brain: A Challenging Diagnosis |
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Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was consistent with anaplastic convexity meningioma which was identical via intraoperative findings. However, the final histology revealed gliosarcoma of the brain. He recovered well postoperatively without any neurological deficit and had completed adjuvant chemoradiotherapy. He was asymptomatic during follow up with no tumour recurrence. Gliosarcoma with predominant sarcomatous component mimicking a meningioma has prolonged survival as compared to a case with predominant glioblastoma component. Hence, the discordance between clinical, radiological, intraoperative and histopathological findings is a challenge in establishing a diagnosis of gliosarcoma. |
format |
Article |
author |
Nornazirah Azizan Nor Haizura Ab Rani Ahmad Toha Samsudin Fadhli Mustaffa Firdaus Hayati |
author_facet |
Nornazirah Azizan Nor Haizura Ab Rani Ahmad Toha Samsudin Fadhli Mustaffa Firdaus Hayati |
author_sort |
Nornazirah Azizan |
title |
Gliosarcoma of a Brain: A Challenging Diagnosis |
title_short |
Gliosarcoma of a Brain: A Challenging Diagnosis |
title_full |
Gliosarcoma of a Brain: A Challenging Diagnosis |
title_fullStr |
Gliosarcoma of a Brain: A Challenging Diagnosis |
title_full_unstemmed |
Gliosarcoma of a Brain: A Challenging Diagnosis |
title_sort |
gliosarcoma of a brain: a challenging diagnosis |
publishDate |
2020 |
url |
https://eprints.ums.edu.my/id/eprint/26480/1/Gliosarcoma%20of%20a%20Brain.pdf https://eprints.ums.edu.my/id/eprint/26480/2/Gliosarcoma%20of%20a%20Brain1.pdf https://eprints.ums.edu.my/id/eprint/26480/ |
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1760230504517337088 |
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13.18916 |