Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model
Two new C15-acetogenins, 4-epi-isolaurallene (1) and 4-epi-itomanallene A (2) were isolated from a population of marine red alga Laurencia nangii Masuda from Carrington Reef. The structures of these compounds were determined intensively by NMR and HRESIMS data. Their configurations were elucidated b...
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2020
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Online Access: | https://eprints.ums.edu.my/id/eprint/25534/1/Two%20new%20epimers%20of%20C15-acetogenin%2C%204-epi-isolaurallene%20and%204-epi-itomanallene%20A%20as%20diastereomeric%20model.pdf https://eprints.ums.edu.my/id/eprint/25534/ https://doi.org/10.1080/14786419.2018.1543681 |
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my.ums.eprints.255342020-06-19T00:14:33Z https://eprints.ums.edu.my/id/eprint/25534/ Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model Phan, Chin Soon Takashi Kamada Charles S. Vairappan QL Zoology Two new C15-acetogenins, 4-epi-isolaurallene (1) and 4-epi-itomanallene A (2) were isolated from a population of marine red alga Laurencia nangii Masuda from Carrington Reef. The structures of these compounds were determined intensively by NMR and HRESIMS data. Their configurations were elucidated by detailed comparison of chemical shifts, germinal protons splitting and NOE correlations with known and synthesized analogues. In addition, antibacterial activities of these compounds were evaluated. These compounds would serve as diastereomeric models for future reference. Since the isolaurallene, neolaurallene, 9-acetoxy-1,10,12-tribromo-4,7:6,13-bisepoxypentadeca-1,2-diene, itomanallene A and laurendecumallene A were isolated, compounds 1 and 2 were the sixth example of C15-acetogenin with dioxabicyclo[7.3.0]dodecene skeleton. Taylor & Francis 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25534/1/Two%20new%20epimers%20of%20C15-acetogenin%2C%204-epi-isolaurallene%20and%204-epi-itomanallene%20A%20as%20diastereomeric%20model.pdf Phan, Chin Soon and Takashi Kamada and Charles S. Vairappan (2020) Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model. National Library Of Medicine, 34 (7). https://doi.org/10.1080/14786419.2018.1543681 |
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Two new C15-acetogenins, 4-epi-isolaurallene (1) and 4-epi-itomanallene A (2) were isolated from a population of marine red alga Laurencia nangii Masuda from Carrington Reef. The structures of these compounds were determined intensively by NMR and HRESIMS data. Their configurations were elucidated by detailed comparison of chemical shifts, germinal protons splitting and NOE correlations with known and synthesized analogues. In addition, antibacterial activities of these compounds were evaluated. These compounds would serve as diastereomeric models for future reference. Since the isolaurallene, neolaurallene, 9-acetoxy-1,10,12-tribromo-4,7:6,13-bisepoxypentadeca-1,2-diene, itomanallene A and laurendecumallene A were isolated, compounds 1 and 2 were the sixth example of C15-acetogenin with dioxabicyclo[7.3.0]dodecene skeleton. |
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Article |
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Phan, Chin Soon Takashi Kamada Charles S. Vairappan |
author_facet |
Phan, Chin Soon Takashi Kamada Charles S. Vairappan |
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Phan, Chin Soon |
title |
Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model |
title_short |
Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model |
title_full |
Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model |
title_fullStr |
Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model |
title_full_unstemmed |
Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model |
title_sort |
two new epimers of c15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene a as diastereomeric model |
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Taylor & Francis |
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2020 |
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https://eprints.ums.edu.my/id/eprint/25534/1/Two%20new%20epimers%20of%20C15-acetogenin%2C%204-epi-isolaurallene%20and%204-epi-itomanallene%20A%20as%20diastereomeric%20model.pdf https://eprints.ums.edu.my/id/eprint/25534/ https://doi.org/10.1080/14786419.2018.1543681 |
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13.160551 |