12Epi -9deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral Xenia sp

• Main Authors: Phan, Chin Soon, Takashi Kamada, Takahiro, Ishii, Toshiyuki Hamada, Charles Santhanaraju Vairappan
• Format: Article
• Language: English
• Published: 2019
• Subjects: SH Aquaculture. Fisheries. Angling
• Online Access: https://eprints.ums.edu.my/id/eprint/25498/1/12-Epi-9-deacetoxyxenicin%2C%20new%20cytotoxic%20diterpenoid%20from%20a%20Bornean%20soft%20coral%2C%C2%A0Xenia%C2%A0s.pdf; https://eprints.ums.edu.my/id/eprint/25498/; https://doi.org/10.1080/14786419.2017.1410812

One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3–4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.