Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula
Red algae of the genus Laurencia have been known to produce a wide array of bioactive secondary metabolites. Here, we report the isolation of two new halogenated chamigrenes, lauremantanones A (1) and B (2), along with seven known compounds, dendroidiol (3), (+)-elatol (4), cartilagineol (5), obtuso...
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my.ums.eprints.254792020-06-04T23:28:05Z https://eprints.ums.edu.my/id/eprint/25479/ Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula Takashi Kamada Phan, Chin Soon Tatsufumi Okino Charles Santhanaraju Vairappan SH Aquaculture. Fisheries. Angling Red algae of the genus Laurencia have been known to produce a wide array of bioactive secondary metabolites. Here, we report the isolation of two new halogenated chamigrenes, lauremantanones A (1) and B (2), along with seven known compounds, dendroidiol (3), (+)-elatol (4), cartilagineol (5), obtusol (6), (+)-laurencenone B (7), 2-chloro-3-hydroxy- α-chamigren-9- one (8), and puertitol A (9), from a population of Laurencia majuscula (Harvey) Lucas from Mantanani Island (North Borneo). The structures of the two new metabolites were determined based on spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds isolated from this alga exhibited potent cytotoxic (HeLa, MCF-7, P-388) and antibacterial (against antibiotic-resistant clinical bacteria) activities. The major metabolite of this population has significant importance in the geographical distribution of this species globally. 2019 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25479/1/Cytotoxicity%20and%20antibacterial%20poteltial%20of%20haligenated%20chamigrenes%20from%20Malaysian%20red%20algae%2C%20Laurencia%20majuscula%20.pdf text en https://eprints.ums.edu.my/id/eprint/25479/2/Cytotoxicity%20and%20antibacterial%20poteltial%20of%20haligenated%20chamigrenes%20from%20Malaysian%20red%20algae%2C%20Laurencia%20majuscula%20%201.pdf Takashi Kamada and Phan, Chin Soon and Tatsufumi Okino and Charles Santhanaraju Vairappan (2019) Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula. Planta Medica International, 6. pp. 36-40. ISSN 2509-9264 https://doi.org/10.1055/a-0977-4418 |
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SH Aquaculture. Fisheries. Angling Takashi Kamada Phan, Chin Soon Tatsufumi Okino Charles Santhanaraju Vairappan Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula |
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Red algae of the genus Laurencia have been known to produce a wide array of bioactive secondary metabolites. Here, we report the isolation of two new halogenated chamigrenes, lauremantanones A (1) and B (2), along with seven known compounds, dendroidiol (3), (+)-elatol (4), cartilagineol (5), obtusol (6), (+)-laurencenone B (7), 2-chloro-3-hydroxy- α-chamigren-9- one (8), and puertitol A (9), from a population of Laurencia majuscula (Harvey) Lucas from Mantanani Island (North Borneo). The structures of the two new metabolites were determined based on spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds isolated from this alga exhibited potent cytotoxic (HeLa, MCF-7, P-388) and antibacterial (against antibiotic-resistant clinical bacteria) activities. The major metabolite of this population has significant importance in the geographical distribution of this species globally. |
format |
Article |
author |
Takashi Kamada Phan, Chin Soon Tatsufumi Okino Charles Santhanaraju Vairappan |
author_facet |
Takashi Kamada Phan, Chin Soon Tatsufumi Okino Charles Santhanaraju Vairappan |
author_sort |
Takashi Kamada |
title |
Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula |
title_short |
Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula |
title_full |
Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula |
title_fullStr |
Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula |
title_full_unstemmed |
Cytotoxicity and antibacterial poteltial of haligenated chamigrenes from Malaysian red algae, Laurencia majuscula |
title_sort |
cytotoxicity and antibacterial poteltial of haligenated chamigrenes from malaysian red algae, laurencia majuscula |
publishDate |
2019 |
url |
https://eprints.ums.edu.my/id/eprint/25479/1/Cytotoxicity%20and%20antibacterial%20poteltial%20of%20haligenated%20chamigrenes%20from%20Malaysian%20red%20algae%2C%20Laurencia%20majuscula%20.pdf https://eprints.ums.edu.my/id/eprint/25479/2/Cytotoxicity%20and%20antibacterial%20poteltial%20of%20haligenated%20chamigrenes%20from%20Malaysian%20red%20algae%2C%20Laurencia%20majuscula%20%201.pdf https://eprints.ums.edu.my/id/eprint/25479/ https://doi.org/10.1055/a-0977-4418 |
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