Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis

• Main Authors: Phan, Chin-Soon, Yee, Chun-Sieng, Charles Santhanaraju Vairappan, Takahiro Ishii, Takashi Kamada
• Format: Article
• Language: English
• Published: 2019
• Subjects: SH Aquaculture. Fisheries. Angling
• Online Access: https://eprints.ums.edu.my/id/eprint/25477/1/Sinulaflexiolide%20P%2C%20a%20cembrane-type%20diterpenoid%20from%20the%20Bornean%20soft%20coral%20Sinularia%20flexibilis.pdf; https://eprints.ums.edu.my/id/eprint/25477/; https://doi.org/10.1007/s10600-019-02668-w

A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A−K (1−11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 μM, respectively.