Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.

• Main Authors: Montgomery Magdalene K., Ruzaidi Mokhtar, Jacqueline Bayliss, Helena C Parkington, Suturin, Victor M, Bruce, Clinton R., Matthew J. Watt
• Format: Article
• Language: English
• Published: Elsevier 2018
• Subjects: QP Physiology
• Online Access: https://eprints.ums.edu.my/id/eprint/22368/1/Perilipin%205%20Deletion%20Unmasks%20an%20Endoplasmic%20Reticulum%20Stress.pdf; https://eprints.ums.edu.my/id/eprint/22368/

Lipid droplets (LDs) are critical for the regulation of lipid metabolism, and dysregulated lipid metabolism contributes to the pathogenesis of several diseases, including type 2 diabetes. We generated mice with muscle-specific deletion of the LD-associated protein perilipin 5 (PLIN5, Plin5MKO ) and...