Chemical diversity and biological activities of Halogenated metabolites from Red Algae Genus Laurencia from Carrington Reef

• Main Author: Toh, Denise Yew Leng
• Format: Academic Exercise
• Language: English
• Published: 2006
• Subjects: QH Natural history
• Online Access: https://eprints.ums.edu.my/id/eprint/20131/1/Chemical%20diversity%20and%20biological%20activities%20of%20Halogenated%20metabolites%20from%20Red%20Algae%20Genus%20Laurencia%20from%20Carrington%20Reef..pdf; https://eprints.ums.edu.my/id/eprint/20131/

This study was carried out on 5 Laurencia species. They are Laurencia snackeyi, Laurencia nangii, Laurencia sp., Laurencia papilose, and Laurencia cribb. Five halogenated secondary metabolites were isolated from L. snackeyi. The halogenated secondary metabolites are (2Z., 6S·, 9R·)-chamigr-2, 5(I4)-dien-8-one (80), Palisadin B (76), 5-acetoxypalisadin B (7), Aplysistatin (6), and 5f3-hydroxypalisadin B (81). The halogenated secondary metabolites were then tested against marine environmental bacteria, human pathogenic bacteria and yeast. (2Z., 6S·, 9R·)chamigr- 2, 5(l4)-dien-8-one (80) and Palisadin B (76) did not show any positive activity against aU of them 5-acetoxypalisadin B (7) and Aplysistatin (6) showed positive activity against 5 marine environmental bacteria which were Clostridium cellobioparum, Clostridium sordelli, Clostridium novyi, Vibrio arginolyticus and Vibrio parahaemolyticus. 5f3-hydroxypalisadin B (81) showed positive activity against 2 marine environmental bacteria which were Clostridium sordelli and Vibrio parahaemolyticus, 2 human pathogenic bacteria Vibrio chlolera and E. coli, and 2 different strains of Candida albicans yeast.