Two new Lobane Diterpene from a Bornean Soft Coral, Sinularia sp.

• Main Authors: Chin, Soon Phan, Shean, Yeaw Ng, Takashi Kamada, Charles Santhanaraju Vairappan
• Format: Article
• Language: English; English
• Published: Natural Product Communications 2015
• Subjects: SH Aquaculture. Fisheries. Angling
• Online Access: https://eprints.ums.edu.my/id/eprint/18508/1/Two%20New%20Lobane%20Diterpene%20from%20a%20Bornean%20Soft%20Coral.pdf; https://eprints.ums.edu.my/id/eprint/18508/7/Two%20new%20lobane%20diterpenes%20from%20a%20Bornean%20soft%20coral%20Sinularia.pdf; https://eprints.ums.edu.my/id/eprint/18508/

Two new lobane diterpenoids, prenyl-a-elemenone (1), ent-prenyl-ß-elemene (2) (stereoisomer), and a known compound, a-murrolene (3) were isolated from a population of Bornean soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of spectroscopic data, including 2D NMR and HR-MS spectra. Compounds were tested for their cytotoxicity and antibacterial activities against antibiotic resistant clinical strains.