Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
The objectives of this study are to determine the antihypertensive activities of leaves and flower of Chassalia curviflora and compare the potential between two different extraction methods which are hot water and methanol extract. The biuret protein assay was conducted to determine the protein prot...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/8277/1/Antihypertensive_Activity_and_Phytochemicals_Analysis_of_Chassalia_curviflora_Extracts.pdf http://umpir.ump.edu.my/id/eprint/8277/4/Antihypertensive%20Activity%20and%20Phytochemicals%20Analysis%20of%20Chassalia%20curviflora%20Extracts.pdf http://umpir.ump.edu.my/id/eprint/8277/ |
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| Summary: | The objectives of this study are to determine the antihypertensive activities of leaves and flower of Chassalia curviflora and compare the potential between two different extraction methods which are hot water and methanol extract. The biuret protein assay was conducted to determine the protein protein concentration in samples. The
phytochemical in leaves and flower extracts of C. curviflora were analyzed by using GC-MS. The result of protein concentration in C. curviflora flower was higher
compared to leaves extract of 0.6648 mg/ml and 0.5431 mg/ml, respectively. The hot water extract of C. curviflora flower showed the highest antihypertensive activity
with the percentage of ACE inhibitory activity of 95.50 ± 0.06% with IC50 value of 3.71 μg/ml. The 10 highest peak area (%) of phytochemical in all samples were:
bis(2-ethylhexyl) ester (34.64 %), Cyclotrisiloxane, hexamethyl- (31.14 %), (Phenylthio)acetic acid, 1-adamantylmethyl ester (30.90 %), Hexanedioic acid,
Cyclononasiloxane, octadecamethyl- (18.357 %), Oleic Acid (16.56 %), n-Hexadecanoic acid (15.23 % and 14.15 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-
methyl- (16.43 % and 12.98 %) and Trichloromethane (11.03 %). In conclusion, both of leaves and flower of C. curviflora have a potential as antihypertensive agent.
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