Anticholinesterase Inhibitory Activity of Quaternary Alkaloids from Tinospora crispa

• Main Authors: M. M., Yusoff, Hazrulrizawati, Hamid, Houghtan, Peter
• Format: Article
• Language: English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2014
• Subjects: QD Chemistry
• Online Access: http://umpir.ump.edu.my/id/eprint/4856/1/Molecules_2014___Tinospora_Crispa.pdf; http://umpir.ump.edu.my/id/eprint/4856/4/Anticholinesterase%20Inhibitory%20Activity%20of%20Quaternary%20Alkaloids%20from%20Tinospora%20crispa.pdf; http://umpir.ump.edu.my/id/eprint/4856/; http://dx.doi.org/10.3390/molecules19011201

Quaternary alkaloids are the major alkaloids isolated from Tinospora species. A previous study pointed to the necessary presence of quaternary nitrogens for strong acetylcholinesterase (AChE) inhibitory activity in such alkaloids. Repeated column chromatography of the vine of Tinospora crispa extrac...