Biological evaluation of folic acid functionalized nano‐zeolitic imidazolate framework‐8 for cancer therapy
Conventional chemotherapy often results in toxicity to normal cells and hampers cancer treatment efficacy. Cancer targeting via surface-functionalized nanocarrier offers an excellent opportunity for tackling this unwanted issue. However, a comprehensive understanding of its toxicity and safety in bi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Springer Berlin Heidelberg
2024
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/43163/1/Biological%20evaluation%20of%20folic%20acid%20functionalized%20nano%E2%80%91zeolitic%20for%20cancer%20therapy.pdf http://umpir.ump.edu.my/id/eprint/43163/2/Biological%20evaluation%20of%20folic%20acid_ABST.pdf http://umpir.ump.edu.my/id/eprint/43163/ https://doi.org/10.1007/s00396-024-05357-5 https://doi.org/10.1007/s00396-024-05357-5 |
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| Summary: | Conventional chemotherapy often results in toxicity to normal cells and hampers cancer treatment efficacy. Cancer targeting via surface-functionalized nanocarrier offers an excellent opportunity for tackling this unwanted issue. However, a comprehensive understanding of its toxicity and safety in biological entities remains limited. In this study, we report the cancer-selectivity of surface-functionalized nano-zeolitic imidazolate framework-8 (FA@nZIF-8) and its safety characteristics in small organisms including zebrafish embryos and brine shrimp. The FA@nZIF-8 exhibited higher selectivity (3.95) towards cancer cells (MCF7) compared to pure nZIF-8. Moreover, this functionalized nano-ZIF-8 not only enhanced permeability performance but also appeared to be a significant survivability advantage, 80% (P < 0.001) with a higher survival rate compared with pure nZIF-8 at the 96-h mark. No scoliosis appeared in healthy zebrafish embryos for both nanoparticle systems. Monitoring brine shrimps showed minimal toxicity induction at a certain level of concentration. This study suggests that surface-functionalized FA@nZIF-8, with its cancer-selective behavior and promising safety characteristics, has bright potential for further exploration in cancer therapy. |
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