Design, synthesis, structural characterization, cytotoxicity and computational studies of Usnic acid derivative as potential anti-breast cancer agent against MCF7 and T47D cell lines

• Main Authors: Roney, Miah, Wong, Kelvin Khai Voon, Uddin, Md. Nazim, Rullah, Kamal, Septama, Abdi Wira, Antika, Lucia Dwi, Mohd Fadhlizil Fasihi, Mohd Aluwi
• Format: Article
• Language: English
• Published: Elsevier Ltd 2025
• Subjects: HD Industries. Land use. Labor; T Technology (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/43154/1/Design%2C%20synthesis%2C%20structural%20characterization%2C%20cytotoxicity%20and%20computational%20studies%20of%20Usnic%20acid%20derivative%20as%20potential%20anti-breast%20cancer%20agent%20against%20MCF7%20and%20T47D%20cell%20lines.pdf; http://umpir.ump.edu.my/id/eprint/43154/; https://doi.org/10.1016/j.compbiolchem.2024.108303

Development of novel inhibitors is necessary to counteract the rising prevalence of breast cancer (BC) in women in recent years, as evidenced by the side-effect profiles of a few clinically approved inhibitors. In this study, the usnic acid derivative (UA1) was synthesized due to the effectiveness o...