Exploring the potential of biologically active phenolic acids from marine natural products as anticancer agents targeting the epidermal growth factor receptor

• Main Authors: Roney, Miah, Issahaku, Abdul Rashid, Huq, A. K. M. Moyeenul, Soliman, Mahmoud E. S., Saiful Nizam, Tajuddin, Mohd Fadhlizil Fasihi, Mohd Aluwi
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2023
• Subjects: HD Industries. Land use. Labor; R Medicine (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/41758/1/Exploring%20the%20potential%20of%20biologically%20active%20phenolic%20acids%20from%20marine%20natural%20products%20as%20anticancer%20agents%20targeting%20the%20epidermal%20growth.pdf; http://umpir.ump.edu.my/id/eprint/41758/2/Exploring%20the%20potential%20of%20biologically%20active%20phenolic%20acids%20from%20marine%20natural%20products%20as%20anticancer%20agents%20targeting%20the%20epidermal%20growth%20factor%20receptor.pdf; http://umpir.ump.edu.my/id/eprint/41758/; https://doi.org/10.1080/07391102.2023.2276879

The epidermal growth factor receptor (EGFR) dimerizes upon ligand bindings to the extracellular domain that initiates the downstream signaling cascades and activates intracellular kinase domain. Thus, activation of autophosphorylation through kinase domain results in metastasis, cell proliferation,...