Identification of β-cycloidal-derived mono-carbonyl curcumin analogs as potential interleukin-6 inhibitor to treat wound healing through QSAR, molecular docking, MD simulation, MM-GBSA calculation

• Main Authors: Forid, Md Shaekh, Patil, Rajesh B., Roney, Miah, Huq, A. K. M. Moyeenul, Mohd Hamzah, Mohd Nasir, Mohd Fadhlizil Fasihi, Mohd Aluwi, Muhammad Saupi, Azuri, Wan Maznah, Wan Ishak
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2024
• Subjects: HD Industries. Land use. Labor; TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/41683/1/Identification%20of%20%CE%B2-cycloidal-derived%20mono-carbonyl%20curcumin%20analogs%20as%20potential%20interleukin-6%20inhibitor%20to%20treat%20wound%20healing%20through%20QSAR.pdf; http://umpir.ump.edu.my/id/eprint/41683/2/Identification%20of%20%CE%B2-cycloidal-derived%20mono-carbonyl%20curcumin%20analogs%20as%20potential%20interleukin-6%20inhibitor%20to%20treat%20wound%20healing%20through%20QSAR%2C%20molecular%20docking%2C%20MD%20simulation%2C%20MM-GBSA%20calculation.pdf; http://umpir.ump.edu.my/id/eprint/41683/; https://doi.org/10.1080/07391102.2024.2331089

Interleukin-6 (IL-6) is a cytokine that involved in the different phases of wound healing. It is responsible for promoting inflammation, regulating tissue repair scar formation, stimulating the production of extracellular matrix components and recruiting immune cells to the wound site. Therefore, su...