Virtual screening of pyrazole derivatives of usnic acid as new class of anti-hyperglycemic agents against PPARγ agonists

• Main Authors: Roney, Miah, Issahaku, Abdul Rashid, Mohd Fadhlizil Fasihi, Mohd Aluwi
• Format: Article
• Language: English; English
• Published: Springer 2023
• Subjects: Q Science (General); TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/40824/1/Virtual%20screening%20of%20pyrazole%20derivatives%20of%20usnic%20acid.pdf; http://umpir.ump.edu.my/id/eprint/40824/2/Virtual%20screening%20of%20pyrazole%20derivatives%20of%20usnic%20acid%20as%20new%20class.pdf; http://umpir.ump.edu.my/id/eprint/40824/; https://doi.org/10.1007/s40203-023-00176-y; https://doi.org/10.1007/s40203-023-00176-y

The finest sources of therapeutic agents are natural products, and usnic acid is a secondary metabolite derived from lichen that has a wide range of biological actions, including anti-viral, anti-cancer, anti-bacterial, and anti-diabetic (hyperglycemia). Based on the hyperglycemia activity of UA, th...