Optimization of single-step pravastatin production by Penicillium brefeldianum ESF21P through response surface methodology

• Main Authors: Seydametova, Emine, Norazwina, Zainol, Convey, Peter
• Format: Article
• Language: English; English
• Published: World Research Association 2023
• Subjects: QD Chemistry; TA Engineering (General). Civil engineering (General); TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/38688/1/Optimization%20of%20Single-step%20Pravastatin%20Production%20by%20Penicillium%20brefeldianum.pdf; http://umpir.ump.edu.my/id/eprint/38688/2/Optimization%20of%20single-step%20pravastatin%20production%20by%20Penicillium%20brefeldianum%20ESF21P%20through%20response%20surface%20methodology_ABS.pdf; http://umpir.ump.edu.my/id/eprint/38688/; https://doi.org/10.25303/1803rjbt49056; https://doi.org/10.25303/1803rjbt49056

The aim of the present study was to optimize the fermentation process for enhanced production of pravastatin by a wild-type Penicillium brefeldianum ESF21P strain using statistical approaches. Initial screening of significant variables influencing pravastatin production was carried out using 27-3 fr...