Structure-based virtual screening towards the discovery of usnic acid derivatives as novel mTOR inhibitor to treat breast cancer

• Main Authors: Wong, Kelvin Khai Voon, Baharudin, Nurul Farina Natasya, Roney, Miah, Mohd Aluwi, Mohd F. F.
• Format: Article
• Language: English
• Published: Penerbit Universiti Malaysia Pahang 2022
• Subjects: QD Chemistry; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://umpir.ump.edu.my/id/eprint/36597/1/Structure%20Based%20Virtual%20Screening%20Towards%20The%20Discovery.pdf; http://umpir.ump.edu.my/id/eprint/36597/; https://doi.org/10.15282/cst.v2i1.8674; https://doi.org/10.15282/cst.v2i1.8674

In this study, mTOR is chosen as the main target for breast cancer treatment. While the existing drugs still pose severe side effects, research on finding new anti-cancer drug should be done continuously. Usnic acid (UA) has been studied for its wide range of biological properties and potential in p...