Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes

• Main Authors: Pal, Arpita, Roy, Sudeep, Kumar, Akhil, Mahmood, Syed, Nasrin, Khodapanah, Thomas, Sabu, Agatemor, Christian, Ghosal, Kajal
• Format: Article
• Language: English
• Published: American Chemical Society 2020
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf; http://umpir.ump.edu.my/id/eprint/31392/; https://doi.org/10.1021/acsomega.0c01228; https://doi.org/10.1021/acsomega.0c01228

This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexa...