Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.

• Main Authors: Mohd Akmal, Azhar, Mimi Sakinah, Abdul Munaim
• Format: Article
• Language: English
• Published: Taylor & Francis 2020
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf; http://umpir.ump.edu.my/id/eprint/30455/; https://www.tandfonline.com/loi/iddi20; https://doi.org/10.1080/03639045.2020.1862176

In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boular...